摘要
目的 观察三苯氧胺并米索前列醇 (米索 )抗早孕的临床效果 ,同时与米非司酮合并米索作临床随机对比观察 ,评价其可行性 ,为临床提供一种新的抗早孕方法。方法 1 97例妊娠≤ 56d的妇女 ,按随机表分为两组。结果 研究组完全流产 83例 (84.7% ) ,对照组 90例 (90 .9% ) ,两组比较差异无显著性 ,P >0 .0 5 ;研究组阴道出血时间 (1 0 .3± 5 .1 )d,较对照组 (1 4 .0± 6 .4)d明显缩短 ,1 5d内阴道出血停止者 ,研究组 64例 (77.1 % ) ,对照组 48例 (53.3 % ) ,两组比较差异非常显著 ,P <0 .0 1 :研究组服三苯氧胺后大多数早孕反应未见明显加重 ,而对照组服米非司酮后大多数早孕反应症状进一步加重 ,副反应明显增加 (P <0 .0 1 )。结论 三苯氧胺并米索能有效终止早孕 ,具有抗早孕作用 ,且药物副反应小 ,价格便宜 ,流产后出血时间短 ,完全流产率与米非司酮接近 。
Objective To evaluate the clinical effect of tamoxifen with misoprotol on terminating early pregnancy and compare it with that of mifepristone with misoprostol.Methods One hundred and ninety seven pregnancy women (≤56 d) were randomly divided into two groups,98 cases in experiment group received tamoxifen 20 mg daily for 4 days,with a total dosage of 80 mg,then misoprostol 800 mg was placed into the vagina on the fifth and sixth day.99 cases of control group received mifepristone 50 mg daily for 3 days,with a total dosage of 150 mg,besides,misoprostol 600 μg was taken at 8 am on the fourth day.Results The complete abortion rate,incomplete abortion rate and failure rate in experiment group were 84.7%(83/98),7.1%(7/98) and 8.2%(8/98) respectively,compared with 90.9%(90/99),6.1%(6/99) and 3.0%(3/99) in control group,there were no significant differences between two groups (P>0.05). The everage days of vaginal bleeding were 10.3±5.1 in experiment group versus 14.0±6.4 in control group,there were significant differences between two groups (P<0.01).Conclusion Tamoxifen with misoprostol could effectively terminate early pregnancy and could be used as one of the antigestational methods.
出处
《河北医药》
CAS
2001年第11期810-812,共3页
Hebei Medical Journal
基金
河北省计划生育委员会 2 0 0 0年资助课题
