摘要
本文在用形态学与组化手段证实神经节苷脂GM3促进国人白血病细胞系J6-2分化的基础上,研究了分化前后细胞鞘糖脂及磷脂组分的变化。作者用自行提纯的GM3表明,J6-2细胞在分化前后没有显著的神经节苷脂组分的改变,中性鞘糖脂组分CMH在分化后明显增多。GM3使LPC、SPM及PI+PS等磷脂组分减少,但使PC组分增多。此项结果提示了神经节苷脂的一个新的功能——调节磷脂代谢,但其具体机制尚待阐明。
By morphological and histochemical methods, the authors demonstrated the differentiation of J6-2 leukemic cells induced by exogenous ganglioside GM3, and studied the change of glycosphingolipid and phospholipid composition after differentiation. The results showed that the main ganglioside component was GM3, and no significant changes were seen after differentiation. The neutral GSL component CMH and phospholipid component PC were shown to increase after differentiation, and lyso-PC, sphingomyelin, PI+PS were shown to decrease. This study suggests a new function of ganglioside——regulation of phospholipid metabolism, the mechanism of which remains to be elucidated.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1992年第2期123-127,共5页
Progress In Biochemistry and Biophysics
基金
自然科学基金
关键词
白血病细胞
鞘糖脂
神经节苷脂
Leukemic cells, Ganglioside GM3, Glycosphingolipids, Phospholipids, Differentiation inducer
