摘要
目的观察壳聚糖-羧甲基壳聚糖作为牙周引导组织再生膜的生物相容性。方法采用冷冻干燥法制备壳聚糖-羧甲基壳聚糖膜,然后通过细胞毒性试验、肌内植入试验等体内外生物学试验相结合的方法研究其生物相容性。结果测试表明,壳聚糖-羧甲基壳聚糖膜无毒,膜植入早期出现巨噬细胞为主的炎症反应;随着膜的降解,炎症反应逐渐减轻,周围组织无不良反应。结论壳聚糖-羧甲基壳聚糖膜具有良好的生物相容性。
Objective To investigate the biocompatibility of chitosan-carboxymethylchitosan as membrane for periodontal guided tissue regeneration(GTR).Methods Chitosan-carboxymethylchitosan blending membrane was prepared by freeze-drying and tests including cytotoxicity test,inserting the membrane into the rabbits ,muscles,were employed to investigate its biocompatibility.Results Chitosan-carboxymethylchitosan blending membrane showed no toxicity.In early period after the insertion of the membrane,inflammatory processes with macrophages were observed,but the processes reduced with the membrane degradation.Conclusion Chitosan-carboxymethylchitosan blending membrane has desirable biocompatibility.
出处
《上海口腔医学》
CAS
CSCD
2003年第5期362-365,共4页
Shanghai Journal of Stomatology
基金
山东省自然科学基金(Y98C09038)
