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基因芯片技术在微生物学研究中的应用 被引量:7

Applications of Gene Chip in Microbial Systems
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摘要 近年来 ,基因芯片技术的诞生使得在一个实验中就可以同时对成千上万个基因进行转录水平的表达和DNA同源性分析成为可能。该项技术已被应用于揭示许多微生物体的转录表达和基因组的差异 ,随着越来越多的微生物基因组全序列测定的完成 ,基因芯片正逐渐成为许多微生物学研究领域中的一项常规技术。归纳了该技术在微生物生理 ,致病性 ,流行病学 ,生态 ,进化 ,代谢工程及发酵优化等研究中的应用。 Gene chip technology allows a parallel analysis of RNA abundance and DNA homology for thousands of genes in a single experiment. Over the past years, this powerful technology has been used to explore transcriptional profiles and genome differences for a variety of microorganisms, greatly facilitating our understanding of microbial metabolism. With the increasing availability of complete microbial genomes, gene chips are becoming a common tool in many areas of microbial research, including microbial physiology, pathogenesis, epidemiology, ecology, phylogeny, pathway engineering and fermentation optimization. ;
出处 《中国生物工程杂志》 CAS CSCD 2003年第8期61-65,共5页 China Biotechnology
基金 江南大学人才引进专项基金资助项目 ( 10 10 0 0 - 2 10 5 3 5 0 0 )
关键词 基因芯片技术 微生物学 基因表达谱 基因组 Gene chip Gene expression profiling Genome Microbial systems
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