摘要
目的 :比较口腔正常、炎症及鳞癌组织内巨噬细胞和微血管数 ,鳞癌组织侵入的巨噬细胞和血管生成的相互关系。方法 :采用免疫组织化学的方法观察巨噬细胞及微血管。结果 :巨噬细胞记数在鳞癌组织内、正常黏膜及炎症组织内均有差别 (P <0 .0 0 1) ,炎症组织内最多 ,鳞癌次之 ,正常黏膜内最少。微血管记数在鳞癌和炎症组织内较正常黏膜内均有增加 (P <0 .0 0 1) ,但在鳞癌内与炎症组织内两者差别无统计学意义 (P >0 .0 5 )。在鳞癌中随病理分级的增加 ,巨噬细胞的侵入增加 (P <0 .0 5 ) ,微血管记数虽稍有增加但无统计学意义 (P >0 .0 5 ) ;巨噬细胞记数与微血管记数呈直线相关关系 ,呈正相关 (P <0 .0 1) ,巨噬细胞侵入在肿瘤坏死区域明显增多。结论 :在口腔鳞癌中侵入的巨噬细胞与肿瘤的血管生成有关 ,其在口腔鳞癌中的具体作用仍需进一步研究 ,阻止巨噬细胞侵入可以作为口腔鳞癌治疗的新靶点。
Objective: To investigate the relationship between macrophage infiltration and angiogenesis in oral squamous cell carcinoma.Methods: Macrophage and angiogenesis was determined by immunohistochemistry. The Immunohistostaining of macrophage and microvessel was counted in most active areas under a light microscope. Results: The mean macrophage counts in tumors was significantly higher than the counts in normal epithelia; The mean microvessel counts in inflammation epithelia and in tumors were not significantly different, but both were higher than that in normal epithelia (P<0 001). Microvessel counts were strongly correlated with macrophage counts in tumors (P<0.01),and high numbers of macrophages often were seen to lie with tumor stroma around the areas of necrosis. macrophage counts were significantly correlated with pathological grades (P<0.05) of th tumor. Conclusion: Tumor associated macrophages may play a major role in the regulation of angiogenesis in oral squamous cell carcinoma. Necrosis may attract macrophage into the tumor.
出处
《贵阳医学院学报》
CAS
2003年第1期9-11,14,共4页
Journal of Guiyang Medical College
关键词
癌
鳞状细胞
口腔肿瘤
巨噬细胞
新生血管化
carcinoma,squamous cell
mouth neoplasms
macrophages
neovascularization
