期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

单核细胞趋化蛋白-1在口腔鳞癌中的表达及意义

The Expression of Monocyte Chemoattractant Protein-1 and Its Clinical Significance In Human Oral Squamous Cell Cancer
暂未订购
导出
摘要 目的: 探讨单核细胞趋化蛋白-1(monocytechemoattractantprotein-1,MCP-1)在口腔鳞癌组织中的表达及其临床意义。方法:应用免疫组织化学SABC法检测41例口腔鳞癌组织中MCP-1的表达,并以10例正常口腔黏膜组织作为对照。结果:口腔鳞癌组织中MCP-1的表达较正常组织增加,差异有统计学意义;口腔鳞癌中MCP-1阳性表达主要分布在癌细胞和巨噬细胞的胞浆中,MCP-1的表达与肿瘤细胞的分化和转移有关。结论:MCP-1可能参与了口腔鳞癌的发展和转移。 Objective: To study the expression of monocyte chemoattractant protein-1 (MCP-1)in the tissue of oral squamous cell cancer (OSCC) and its clinical significance. Methods: The expression of MCP-1 in 41 cases of OSCC and 10 specimens of normal oral epithelial tissue was assessed with SABC immunohistochemical method. Results: The expression of MCP-1 was higher in OSCC than in normal oral mucous tissue. There was a relation between the expression of MCP-1 and tumor differentiation and lymphatic metastasis. Conclusion: MCP-1 might participate the progress and lymphatic metastasis of human OSCC.
作者 杨建斌 冯红超 宋宇峰
机构地区 贵阳医学院附院口腔科
出处 《贵阳医学院学报》 CAS 2005年第2期111-113,共3页 Journal of Guiyang Medical College
基金 贵州省第二批跨世纪人才省政府专项基金--黔科合人专字(2000)9813号
关键词 单核细胞趋化蛋白-1 表达及 免疫组织化学SABC法 口腔鳞癌组织 MCP-1 口腔黏膜组织 临床意义 正常组织 巨噬细胞 阳性表达 肿瘤细胞 统计学 癌细胞 转移 carcinoma, squamous cell mouth monocyte chemoattractant protein-1 immunohistochemistry
分类号 R587.2 [医药卫生—内分泌] R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献11

  • 1宋宇峰,冯红超.口腔鳞癌巨噬细胞侵入与肿瘤血管生成的关系[J].贵阳医学院学报,2003,28(1):9-11. 被引量：9
  • 2Hisashi Saji, Morio Kioke. Significant correclation of monocyte chemoattractant protein-1 expression with neovascucarization and progression of breast carcinoma [ J ]. Cancer, 2001,92:1 085 - 1 091.
  • 3Rollins B J, A Walz, M Baggiolini. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes [ J]. Blood, 1991,78:1 112.
  • 4Valente A J, Graves C E, Vialle - Valentin R, et al. Puri fication of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture [ J ]. Biochemistry,1998,27:4 162.
  • 5Allavena P, G Bianchi, D Zhou, et al. Induction of naturalkiller cell migration by monocyte chemotactic protein-1, 2,-3 [J]. EurJ Immunol, 1994, 24:3233.
  • 6Carr M W, S J Roth, E Luther, et al. Monocyte chemoattractant protein-1 act as a T-lymphocyte chemoattractant [J]. Proc Natl Acad Sci USA,1994,91:3 652.
  • 7Yoshimurra T, E J Leonard. Identification of high affinity receptors for human monocyte chemoattractant protein-1 on human monocytes [J]. Immunol, 1990,145:292.
  • 8Charo I F, S J Myers, A Herman, et al. Molecular cloning and functional expression of two monocyte chemoattractant protein-1 receptors reveals alternative splicing of the carboxyl-terminal tails [ J ]. Proc Natl Acad Sci USA, 1994, 91:2 752.
  • 9Rosalbo Salcedo, Maria Lourdes Ponce. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression [ J ]. Blood,2000, 96 ( 1 ): 34 - 40.
  • 10冯红超,宋宇峰,温玉明.口腔癌组织中血管内皮生长因子-C在肿瘤相关巨噬细胞内的表达及与淋巴结转移的关系[J].癌症,2004,23(3):278-281. 被引量：27

二级参考文献21

  • 1景纯,温玉明,王大章,王昌美.口腔颊、舌鳞癌癌周淋巴管形态学特征与颈淋巴结转移[J].华西口腔医学杂志,1995,13(2):130-134. 被引量：26
  • 2[1]Leek RD, Lewis CE, Whitehouse R,et al. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma[J]. Cancer Res, 1996,56(20):4625～4629.
  • 3[2]Weidner N, Carroll PR,Flax J,et al.Tumor angiogenesis correlation with metastasis in invasive postate carcinoma[J].Am J Pathol,1993,143:755-761.
  • 4[3]Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease [J]. Nature Med, 1995,1:27-31.
  • 5[4]O'Sullivan C,and Lewis C E. Tumor-associates leucocytes:friends or foes in breast carcinoma[J].J Pathol 1994,172:229-235.
  • 6[5]Liss C, Fekete MJ, Hasina R, et al. Paracrine angiogenic loop between head-and-neck squamous-cell carcinomas and macrophages[J]. Int J Cancer, 2001,93(6):781-785.
  • 7[6]Crowther M, Brown NJ, Bishop ET,et al. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors[J]. J Leukoc Biol,2001,70(4):478-490.
  • 8[7]Yanagawa H, Takeuchi E, Suzuki Y,et al. Production of interleukin-10 by alveolar macrophages from lung cancer patients [J]. Respir Med,1999,93(9):666-671.
  • 9[8]Vukanovic J, Isaacs JT. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers [J]. Cancer Res,1995,55(7):1499-1504.
  • 10[9]Joseph IB, Isaacs JT. Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents [J]. J Natl Cancer Inst ,1998,90(21):1648～1 653.

共引文献32

贵阳医学院学报
2005年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部