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口腔鳞癌中单核细胞趋化蛋白-1在巨噬细胞浸润、聚集中的意义 被引量：10

The Significance of Monocyte Chemoattractant Protein-1 in Macrophage Infiltration, Recruitment in Human Oral Squamous Cell Cancer
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摘要 目的:探讨口腔鳞癌中单核细胞趋化蛋白-1(monocyte chemoattractant protein-1MCP-1)表达与肿瘤中浸润巨噬细胞的关系。方法:应用免疫组化方法检测口腔鳞癌中MCP-1的表达和巨噬细胞的浸润,光镜进行高倍视野下巨噬细胞记数和MCP-1表达的分级。结果:在口腔鳞癌中MCP-1的表达与肿瘤分化有关,并与肿瘤内浸润的巨噬细胞有关(P<0.05)。结论:巨噬细胞可能受MCP-1趋化作用的影响,参与肿瘤的生长和转移。 Objective： To investigate the relationship between the expression of Monocyte chemoattractant protein-1（MCP-1）and the macrophage infiltration in oral squamous cell cancer（OSCC）. Methods： After immunohistochemical SABC staining, light microscopes was used for counting macrophages and detect MCP-1 expression. Results： MCP-1 expression was related to macrophage infiltration in OSCC （P〈0.05）. Conclusion： Macrophage infiltration may be influenced by MCP-1 chemotactic affection and participate the growth and lymphatic metastasis in OSCC.
作者 杨建斌 冯红超 宋宇峰
机构地区 贵阳医学院附属医院口腔科
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2005年第20期1155-1157,共3页 Chinese Journal of Clinical Oncology
基金 贵州省第二批跨世纪人才省政府专项基金资助(编号:2000-9813)
关键词 口腔鳞癌 巨噬细胞 单核细胞趋化蛋白-1(MCP-1) Oral squamous cell cancer Macrophage Monocyte chemoattractant protein-1
分类号 R739.8 [医药卫生—肿瘤]
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参考文献12

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二级参考文献21

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共引文献32

同被引文献74

引证文献10

二级引证文献20

中国肿瘤临床
2005年 第20期

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