摘要
本文利用色-质联用法研究了康力龙和氟咱甲氢龙的体内代谢和尿中排泄规律。康力龙的代谢途径主要为16-羟基化,另有3＇-羟基化,4-羟基化,3＇16-二羟基化和4.16-二羟基化,代谢物较多。氟咱甲龙只有一个16-羟基化代谢物。康力龙及代谢物的尿中排泄18h达峰值,分别于33h和42～82h于尿中消失。氟咱甲氢龙及其代谢物的尿中排泄4h即达峰值。并分别于48h和75h以后消失。
The metabolites of stanozol and furazabol in human urine were separated and identified. The differences between their metabolism in man were investigated. The 16-hydrcxylation, which is the only way of furazabcl metabolism, is also the main metabolic pathway of stanozol. In addition, 3'-hydroxylation, 4-hydroxylation, 3', 16-dihydroxylation and 4, 16-dihydroxylation are alsc shown to be the metabolic pathway of stanozol, eight kinds of metabolites are detected in its positive urine. The metabolism of furazabol is much simpler. Excretion of the two drugs and their metabolites were also studied. It took 18 h for stanozol to reach the peak excretion level, its presence in the urine lasted for 33 h. Its metabolites, especially metabolite-4, metabolite-1 and metabolite-6, showed high urinary concentration and lasted for 42～82h. Furazabol and its metabolites, however, were excreted to the peak level only 4 h after oral administration, and lasted for 48 and 75h, respectively. Therefore, stanozol metabclite-4, 1, 6 were chosen to be the characteristic compounds for screening stanozol. For furazabol, the drug itself and its only metabolite were selected for identification purpose.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1992年第9期1019-1022,共4页
Chinese Journal of Analytical Chemistry
关键词
康力龙
氟咱甲氢龙
代谢物
GC/MS
Stanozol
Furazabol
Metabclites
Gas chrcmatography-mass spectra analysis.
