摘要
本文对国际奥委会禁用的19种蛋白同化激素进行了人体服药试验;从尿中富集提取所排泄的这类激素,对它们在人体内的代谢情况进行研究,弄清了各药物的主要代谢途径;获得了药物原型及其主要代谢物的GC,MS数据;在此基础上,建立了系统分析和检测尿中蛋白同化激素的最优化方法。
Nineteen anabolic steroids were separately administerd to healthy men. Anabolic steroid metabolites were isolated and extracted from the collected urine samples following an integrated procedure. The main metabolic pathways of these drugs were made clear after the investigation by GC-MS. Based on the obtained chromatographic- mass spectrometric data of anabolic steroids, a method for large scale and routine analysis of anabolic steroids was set up.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第8期598-605,共8页
Acta Pharmaceutica Sinica
关键词
同化激素
尿样分析
药物
Anabolic steroids
Urine analysis
GC/MS
