摘要
目的 :研究血管内皮生长因子 (VEGF)在肺癌诊断、疗效监测中的临床意义。 方法 :收集 30例正常体检者、2 9例接受放、化疗的肺癌患者、34例肺炎患者和 96例肺癌患者术前及部分术后 1～ 2周静脉血 ,用ELISA方法检测血清VEGF浓度。 结果 :肺癌患者血清VEGF浓度较正常对照组明显升高 ,二者间差异非常显著 (P <0 .0 0 1) ,肺炎患者血清VEGF浓度虽也有一定的升高 ,但较之肺癌组低 ,二者间有显著差异 (P <0 .0 5 )。肺癌术后血清VEGF浓度升高的患者在短期内易发生癌转移 (12 / 2 1,P <0 .0 1)。放疗可以刺激肿瘤细胞表达和分泌VEGF ,故患者接受放疗后 6 0天血清VEGF浓度较放疗前明显增高 ,肿瘤易复发转移。肺癌患者血红蛋白含量与血清VEGF水平也有密切关系。 结论 :检测血清VEGF浓度在肺癌的诊断中有一定的辅助意义 ,但需和肺炎等疾病鉴别。血清VEGF在指导临床医师制订合理的治疗方案、疗效判断。
Objectives:To evaluate the significance of serum vascular endothelial growth facotr(VEGF) in the diagnosis and the determination of curative effects of lung cancers. Methods:Serum levels of VEGF in 30 healthy controls, 34 cases of pneumonia, 29 cases of patients receiving radio and chemotherapy and 96 lung cancers were measured by a sandwich enzyme immunoassay(ELISA). And the results were analyzed with respective clinicopathological factors. Results:Significant differences in the VEGF levels were observed between the controls and the lung cancers( P <0.001) and also between pneumonia and lung cancers( P <0.05).Metastasis was commonly seen in the lung cancer patients who having higher VEGF levels after surgical resection(12/21).X ray irradiation can induct the tumor cells to secret VEGF.The patients having increased serum VEGF levels in 60 days after rediotherapy will have a higher rate of tumor recurrence and metastasis than those with non increased serum VEGF levels. Conclusions:Serum VEGF level is a useful marker for lung cancer diagnosis, tumor metastasis and recurrence.
出处
《医学研究生学报》
CAS
2002年第6期500-501,504,共3页
Journal of Medical Postgraduates
基金
辽宁省自然科学基金资助课题 (批准号 :0 0 2 0 3 2 )
关键词
血管内皮生长因子
肺癌
血红蛋白
Vascular endothelial growth factor
Lung cancer
Hb
