摘要
目的:了解不同病理类型肺癌患者辅助性T细胞亚群(Th1/Th2)的反应状态,探讨肺癌发生发展的免疫机制。方法:收集三种不同病理类型肺癌患者47例(鳞癌23例,腺癌15例,小细胞肺癌9例)、健康志愿者31例的血清,分成肺癌组、正常对照组,用酶联免疫吸附试验(ELISA)检测各组外周血中Th1型细胞因子、白细胞介素2(IL-2)、γ-干扰素(IFN-γ)和Th2型细胞因子IL-4、IL-10的浓度。结果:三种不同病理类型肺癌患者外周血中IL-2、IFN-γ浓度均显著低于正常人组,IL-4、IL-10浓度显著高于正常人组(P<0.05)。结论:腺癌、鳞癌、小细胞非分化癌三种不同病理类型的肺癌患者外周血中的免疫细胞均呈现Th2型免疫反应优势状态,呈现Th1/Th2的漂移状态。
Objective To study the immuno-state in patients with lung cancer with examination of peripheral blood Th1/Th2 related cytokines.Methods Peripheral blood Th1 /Th2 related cytokines（Th1：IL-2,IFN-γ,Th2：IL-4,IL-10）were examined with ELISA in 47 patients with lung cancer（Sqaamous cell carcinoma,n = 23,adenocarcinoma,n = 15,small cell carcinoma,n = 9）and 31 controls.Results In all these lung cancer patients,the peripheral blood IL-2 and IFN-γ contents were significantly lower and the IL-4 and IL-10 contents were significantly higher than those in controls（all P〈 0.05）.Conclusion There was Th2 dominant type of immuno-state in patients with lung cancer.
出处
《放射免疫学杂志》
CAS
2010年第5期502-503,共2页
Journal of Radioimmanology
