摘要
目的探讨宫颈癌组织中VEGF和nm23-H1蛋白表达作为判断宫颈癌患者预后因素的意义。方法应用免疫组织化学S-P法对105例宫颈癌及10例慢性宫颈炎和20例癌旁组织进行VEGF和nm23-H1蛋白产物检测,并对宫颈癌患者化疗后进行5a以上随访,分析它们与宫颈癌患者复发、转移及预后的关系。结果慢性宫颈炎组织中VEGF表达均为阴性,nm23-H1表达阳性率为90.0%;癌旁组织VEGF阳性表达率为45.0%,nm23-H1阳性表达率为75.0%;宫颈癌组织中VEGF阳性表达率为72.4%,nm23-H1阳性表达率为47.6%。VEGF阳性表达和nm23-H1阴性表达与宫颈癌患者局部复发(分别为P<0.05,P<0.01),转移(分别为P<0.01,P<0.05)和较短的生存期(分别为P<0.01,P<0.01)密切相关。VEGF蛋白表达与nm23-H1蛋白表达呈负相关(P<0.05)。结论宫颈癌活体组织检测标本中VEGF和nm23-H1的表达与肿瘤的浸润、转移及预后密切相关,可作为预测宫颈癌患者的预后因素。
[Objective] To evaluate the prognostic significance of VEGF and nm23-H1 expression for patients with cervical carcinoma. [Methods] The expression of VEGF and nm23-H1 were examined by immunohistochemistory S-P staining in 105 cervical carcinoma tissues and 10 chronic cervicitis tissues as well as 20 paracancerous tissues, with follow-up of more than 5 years for the 105 patients with cervical carcinoma after operation. The immunohistochemical data were correlated with relapse, distant metastasis and survival. [Results] No one positive expression of VEGF and 90.0% positive expression of nm23-H1 in chronic cervicitis tissues. 45.0% positive expression of VEGF and 75.0% nm23-H1 in paracancerous tissues.72.4% positive expression of VEGF and 47.6% of nm23-H1 in cervical cancinoma tissues. Positive expression of VEGF and negative expression of nm23-H1 correlated with relapse （P 〈0.05, P〈0.01） and the development of distant metastasis （P〈0.01;P〈0.05） as well as shorter survival （P〈0.01; P 〈0.05）. The expression of VEGF was negatively correlated with the expression of nm23-H1（P〈0.05）. [Conclusion] The results of the study show that the VEGF and nm23-Ht expression are significant prognostic factors for patients with cervical carcinoma and indicate that the high level expression of VEGF and low level expression of nm23-H1 may be associated with the infiltrating development and poor prognosis of cervical carcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第20期3093-3095,3098,共4页
China Journal of Modern Medicine
