摘要
小鼠的继发性细粒棘球蚴囊在含甲苯达唑阿苯达唑或阿苯达唑亚枫1及10μg/ml的培养液中培养l～7d时,囊壁所含各药物的量相近,但生发层的受损以甲苯达唑组较重,次为阿苯达唑亚砜和阿苯达唑组。感染小鼠ig上述3种苯并咪唑类化合物的等效剂量1～14d后24h,囊壁的药物含量甚低,但生发层的损害仍以甲苯达唑组的较重,并认为阿苯达唑亚矾是阿苯达唑的有效代谢物。
When secondary cysts of Echinococcus granulosus, removed out from mice infected with protoscoleces 12-14 months previously, maintained in vitro were exposed to mebendazole (Meb), albendazole (Alb) or albendazole sulfoxide (AlbSO) at a concentration of 1 or 10 μg / ml for 1, 3 and 7 d, the contents of each drug in cyst wall were similar. Meanwhile, the alteration in germinal layer induced by Meb was more apparent as compared with that induced by AlbSO and Alb. When infected mice were treated ig with Meb, Alb or AlbSO at an equal effective dose of respective 50, 300 and 150 mg/ kg daily for 1, 3, 7 and 14 d, more severe damage in germinal layer was seen in Meb group. In comparison with Alb and AlbSO, the damage in germinal layer induced by the latter was more intensive than that induced by the former. 24h after last dose of each treatment course, much less Meb, Alb or AlbSO was detected in cyst wall. The results indicate that the germinal layer of E. granulosus is more susceptible to Meb than to Alb and AlbSO, and convince that AlbSO is the major effective metabolite of Alb.
出处
《地方病通报》
1992年第1期5-10,共6页
Endemic Diseases Bulletin
关键词
细粒棘球蚴囊
甲苯达唑
阿苯达唑
Echinococcus granulosus cyst
Germinal layer
Mebendazole
Albendazole
Albendazole sulfoxide
