摘要
在疗程为10～14d时,甲苯达唑对小鼠继发性细粒棘球蚴病的最低有效剂量为25mg/kg/d,阿苯达唑的为100mg/kg/d。在所用的疗程下,甲苯达唑的剂量较阿笨达唑100～300mg/kg/d低3～11倍时,它们的疗效相仿,但甲苯达唑100mg/kg/d的疗效则优于剂量大l～2倍的阿苯达唑。甲苯达唑与阿苯达唑合并治疗未能明显提高疗效,但此2种药物并用吡喹酮治疗则疗效明显提高。实验证明阿苯达 唑亚砜的疗效优于阿苯达唑,而阿苯达唑用则无效。
When mice infected with secondary cysts of Echinococcus granulosus for 4-7 months were treated intragastrically with mebendazole (MBZ) and albendazole (ABZ) in 10-14-day treatment courses, the minimum effective daily doses of the two drugs were 25 mg/ kg and 100 mg/ kg, respectively. With the treatment courses used the effects of MBZ were similar to those produced by oral ABZ at 100-300 mg / kg / d, although the daily doses of MBZ were 3-11-fold less than those of ABZ. Nevertheless, when the infected mice were treated intragastrically with MBZ at a higher daily dose of 100 mg/ kg for 10-121 days, the efficacy was significantly higher than that of ABZ given at daily doses of 200 or 300 mg / kg for 10-14 days. No synergetic effect was observed when the infected mice were treated with MBZ combined with ABZ. However, when MBZ was administered in combination with ABZ and praziquantel to the infected mice, the efficacy was enhanced significantly. The results demonstrated that when the infected imce were treated intragastrically with ABZ and its metabolites albendazole sulfoxide (ABZSO), the efficacy of the latter was significantly higher than that of the former. No apparent effect of albendazole sulphone (ABZSP) was noted in the experimental therapy.
出处
《地方病通报》
1990年第3期11-16,共6页
Endemic Diseases Bulletin
基金
卫生部科学基金
关键词
细粒棘球蚴囊
包虫病
甲苯达唑
Cyst Echinococcus granulosus
Hydatidosis
Mebendazole
Albendazole
Albendazole sulfoxide
Albendazole sulphone
Praziquantel
