摘要
[目的]医用镁合金因其与人体骨骼相近的密度和优异的生物相容性,在骨植入材料领域的应用潜力巨大。然而,其在生理环境中的降解过快,会引发力学完整性过早丧失、局部pH升高及氢气积聚等问题,严重制约其临床推广应用。本研究旨在通过表面改性提升镁合金的耐腐蚀性能并维持其良好的生物相容性。[方法]采用磁控共溅射技术在AZ31镁合金表面制备Mg–Si复合薄膜。通过正交试验优化了溅射的压强、金属靶功率和溅射时间。通过扫描电镜(SEM)、白光干涉仪、电化学分析及模拟体液(SBF)浸泡试验,分析了Mg–Si复合薄膜的表面形貌、表面粗糙度及耐腐蚀性能。并通过CCK-8法和细胞荧光染色评估其体外细胞毒性及生物相容性。[结果]磁控溅射的较优工艺参数为:压强0.30 Pa,镁的溅射功率40 W,硅的溅射功率120 W,溅射时间1 h。在此条件下所获Mg–Si复合薄膜表面均匀致密,表面粗糙度Ra低至30.5 nm。电化学测试表明,该薄膜使基体的腐蚀电流密度降低了近2个数量级,且阳极分支显示出钝化特征,耐蚀性显著提升。体外细胞实验证实,与未处理的AZ31镁合金相比,Mg–Si复合薄膜的细胞增殖率更高,细胞形态更佳,表现出优异的生物相容性。[结论]采用磁控共溅射技术可于AZ31镁合金表面成功制备出兼具优良耐蚀性和生物相容性的Mg–Si复合薄膜,为解决医用镁合金过快降解问题提供了一种有效的表面改性方案。
[Objective]Medical magnesium alloys show great potential in bone implant materials due to their density close to that of human bone and excellent biocompatibility.However,their excessively rapid degradation in physiological environments can lead to premature loss of mechanical integrity,localized pH increase,and hydrogen gas accumulation,which severely limit their clinical application.This study aims to enhance the corrosion resistance of magnesium alloys while maintaining good biocompatibility through surface modification.[Method]A Mg–Si composite film was prepared on the surface of AZ31 magnesium alloy using magnetron co-sputtering.Orthogonal experiments were carried out to optimize the sputtering parameters,including pressure,metal target power,and sputtering time.The surface morphology,roughness,and corrosion resistance of Mg–Si composite film were characterized by scanning electron microscopy(SEM),white light interferometry,electrochemical measurement,and simulated body fluid(SBF)immersion test.In vitro cytotoxicity and biocompatibility were evaluated via CCK-8 assay and cell fluorescence staining.[Result]The optimal magnetron sputtering parameters were determined as follows:pressure 0.30 Pa,Mg target power 40 W,Si target power 120 W,and sputtering time 1 h.The Mg–Si composite film obtained under the optimized conditions exhibited a uniform and compact surface with a low surface roughness(Ra)of 30.5 nm.Electrochemical measurements revealed that the film reduced the corrosion current density of the substrate by nearly two orders of magnitude,and the anodic branch displayed passivation characteristics,indicating significantly improved corrosion resistance.In vitro cell experiments confirmed that the Mg–Si composite film promoted higher cell proliferation rates and better cell morphology compared to the untreated AZ31 magnesium alloy, demonstrating excellent biocompatibility. [Conclusion] A Mg–Si composite film withexcellent corrosion resistance and biocompatibility can be successfully prepared on surface of AZ31 magnesium alloy bymagnetron co-sputtering. This study provides an effective surface modification strategy to address the issue of excessivelyrapid degradation of medical magnesium alloys.
作者
张世坤
侯树森
李文星
张精豪
ZHANG Shikun;HOU Shusen;LI Wenxing;ZHANG Jinghao(School of Mechanical and Electrical Engineering,Henan Institute of Science and Technology,Xinxiang 453003,China;School of Mechanical and Electrical Engineering,Xinxiang University,Xinxiang 453003,China)
出处
《电镀与涂饰》
北大核心
2026年第3期124-131,共8页
Electroplating & Finishing
关键词
镁合金
磁控溅射
镁-硅复合薄膜
耐蚀性
生物相容性
magnesium alloy
magnetron sputtering
magnesium–silicon composite film
corrosion resistance
biocompatibility
