摘要
与传统骨科植入金属材料相比,镁合金除具备良好的机械强度、生物相容性外,还兼具可降解性、骨诱导性及抑菌活性。然而,当前开发的医用镁合金存在耐腐蚀性不足的缺陷,难以满足临床需求。而稀土元素因能有效改善镁合金的耐腐蚀性等关键性能,已成为研发新型医用镁合金的核心添加元素。因此,稀土镁合金的设计、制备及临床转化近年来受到广泛关注。本研究旨在简要探讨生物降解稀土镁合金作为骨科内固定植入物的可行性、面临的挑战及未来前景。
Compared with traditional orthopedic metal implants,magnesium alloys demonstrate superior mechanical strength and biocompatibility,while also exhibiting biodegradability,bone-inducing properties,and antibacterial activity.However,currently developed medical magnesium alloys suffer from insufficient corrosion resistance,failing to meet clinical requirements.Rare earth elements,which can effectively enhance critical properties like corrosion resistance in magnesium alloys,have become the core additive elements for developing new medical magnesium alloys.Consequently,the design,preparation,and clinical translation of rare earth magnesium alloys have garnered significant attention in recent years.This study aims to briefly explore the feasibility,challenges,and future prospects of biodegradable rare earth magnesium alloys as orthopedic internal fixation implants.
作者
岳浩
朱新科
高正超(综述)
孙正明(审校)
YUE Hao;ZHU Xinke;GAO Zhengchao;SUN Zhengming(Department of Orthopedics,Shaanxi Provincial People's Hospital,Xi'an 710068,P.R.China;Graduate School of Xi'an Medical University,Xi'an 710021,P.R.China;Key Laboratory of Basic and Clinical Translation for Bone and Joint Diseases in Shaanxi Province,Xi'an 710068,P.R.China)
出处
《生物医学工程学杂志》
北大核心
2025年第6期1309-1314,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金青年科学基金资助项目(82101453)
陕西省科技创新团队项目(2024RS-CXTD-60)
陕西省人民医院科技发展孵化基金资助项目(2021YJY-42)。
关键词
镁合金
稀土
耐腐蚀性能
临床应用
生物材料
Magnesium alloy
Rare earth
Corrosion resistance
Clinical application
Biomaterials
