摘要
目的探究2019—2021年新型冠状病毒感染疫情防控期间中国、全球及不同社会人口学指数(socio-demographic index,SDI)地区抑郁症疾病负担较1990—2019年间的变化,分析性别-地区差异。方法基于全球疾病负担(Global Burden of Disease,GBD)数据库1990—2021年中国、全球和不同SDI地区的抑郁症相关数据,使用年龄标准化患病率(age-standardized prevalence rate,ASPR)、年龄标化伤残调整生命年(age-standardized disability-adjusted life years,ASR-DALYs)、估计年百分比变化(estimated annual percentage change,EAPC)等指标,描述新型冠状病毒感染疫情防控期间各地区的抑郁症疾病负担的分布特征。使用Joinpoint模型分析负担的时间变化趋势,贝叶斯年龄-时期-队列(Bayesian age-period-cohort,BAPC)模型估算2020、2021年新型冠状病毒感染带来的抑郁症超额疾病负担。结果2021年我国抑郁症ASPR为2875.68/10万(95%CI:2589.96~3203.43),较2019年的2825.00/10万(95%CI:2550.42~3136.08)升高;2021年我国ASR-DALYs为430.61/10万人年(95%CI:305.24~586.21),较2019年的430.14/10万人年(95%CI:303.92~580.82)升高。Joinpoint分析显示,我国抑郁症ASPR在2019年出现拐点,2019—2021年的年度变化百分比(annual percentage change,APC)为0.95(P<0.05)呈现上升趋势,相比全球和各SDI水平地区,我国上升幅度较小。我国抑郁症ASR-DALYs在2019年未拟合到明显拐点,而其他地区ASR-DALYs在2019年附近出现拐点,呈明显上升趋势(P<0.05)。我国新型冠状病毒感染带来的抑郁症超额疾病负担最轻,2021年超额ASPR为121.67(每10万人),超额ASR-DALYs为12.25(每10万人年),全球水平分别为我国的3.6倍和7.0倍。女性的ASPR和ASRDALYs水平均高于男性,女性超额疾病负担高于男性水平,高SDI地区的女性超额疾病负担最重。结论新型冠状病毒感染为全球各地区带来严重的抑郁症超额疾病负担。我国有效的疫情应对政策和心理援助措施,有助于缓解这一负担。对策政府应加大精神卫生保健资源的投入,加强精神卫生知识的宣传,提高全人群对抑郁症的认知水平。面对突发公共卫生事件时,应迅速采取防控措施,保证规律、即时的信息发布,稳定社会情绪,联合基层社会组织实施心理援助与情绪安抚。
Objective To investigate changes in the depressive disorder burden in China,global,and across socio-demographic index(SDI)regions during the COVID-19(from 2019 to 2021)compared with 1990 to 2019,and to analyze sex-regional disparities.Methods Using depressive disorder data from the Global Burden of Disease(GBD)database(from 1990 to 2021)for China,global populations,and 5 SDI regions,we characterized depressive disorder burden distribution during the pandemic via metrics including age-standardized prevalence rate(ASPR),age-standardized disability-adjusted life years(ASR-DALYs),and estimated annual percentage change(EAPC).Joinpoint regression modeled temporal trends,and the Bayesian age-period-cohort(BAPC)model estimated the excess depressive disorder burden attributable to COVID-19 in 2020—2021.Results China's depressive disorder ASPR increased to 2875.68/100000 person-years(95%CI:2589.96 to 3203.43)in 2021 from 2825.00/100000(95%CI:2550.42 to 3136.08)in 2019;ASR-DALYs rose to 430.61/100000(95%CI:305.24 to 586.21)from 430.14/100000 person-years(95%CI:303.92 to 580.82).Joinpoint analysis identified an inflection point for China's ASPR in 2019,with a significant upward annual percentage change(APC=0.95,P<0.05)from 2019 to 2021—a smaller increase than global and other SDI regions.No significant inflection was observed for China's ASR-DALYs,whereas other regions showed clear upward inflection points near 2019(P<0.05).China exhibited the lowest excess depressive disorder burden due to COVID-19:excess ASPR was 121.67/100000 and excess ASR-DALYs was 12.25/100000 person-years in 2021,only 28%and 14%of global levels,respectively.Females had higher ASPR/ASR-DALYs and excess burden than males,with females in high-SDI regions bearing the heaviest burden.Conclusion COVID-19 imposed severe excess depressive disorder burdens worldwide.China's effective pandemic response policies and psychological assistance measures mitigated this burden.Countermeasures Governments should increase investment in mental healthcare resources,enhance public mental health literacy,and ensure rapid implementation of containment measures during public health emergencies—including regular information updates to stabilize public sentiment—alongside communitybased psychological support.
作者
周元植
袁子泉
马佳昕
陈雯雯
张旭
郭丹
和水祥
李雅睿
ZHOU Yuanzhi;YUAN Ziquan;MA Jiaxin;CHEN Wenwen;ZHANG Xu;GUO Dan;HE Shuixiang;LI Yarui(Department of Gastroenterology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,Shaanxi,China;Surgical Intensive Care Unit,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,Shaanxi,China)
出处
《陆军军医大学学报》
北大核心
2026年第4期504-513,共10页
Journal of Army Medical University
基金
国家自然科学基金青年科学基金项目(82303169)。
关键词
抑郁症
新型冠状病毒感染
全球疾病负担
患病率
伤残调整生命年
depressive disorder
Coronavirus Disease 2019
global burden of disease
prevalence
disability-adjusted life years
