摘要
目的评估随机输血中RhCE抗原错配的概率,建立一个适合中国患者的RhCE配型策略。方法根据Landsteiner法则来确定供者和受者的RhCE抗原错配组合,根据中国人Rh血型遗传学参数计算错配概率以及找到匹配供者的机会。结果按照受检者的籍贯和民族分类,对104万例受检者Rh抗原分布数据进行了分析。在随机输血中,北方人和南方人RhD抗原错配概率分别为0.45%和0.39%;RhCE抗原错配概率分别为26.31%和23.60%;RhCE抗原错配概率分别是RhD抗原错配概率的58.73和60.75倍;DCCee是错配的高风险表型,占所有错配的56.01%到62.33%。一个库存100名左右供者的血库,可以为98%的中国患者提供RhCE抗原匹配的血液。结论在RhD同型输血患者中,RhCE抗原错配概率在25%左右,建立一个适合中国患者的RhCE抗原配型策略将有助于优化个体化精准输血。
Objective To estimate the probability of RhCE antigen mismatch in random blood transfusions and establish a RhCE typing strategy suitable for patients in China.Methods The RhCE antigen mismatch between donor and recipient were determined by Landsteiner's rule.The calculation of mismatch probability and the chance of finding a matching donor were determined by the genetic parameters of Rh blood type in Chinese individuals.Results The Rh antigen distribution data of 1.04 million subjects were analyzed according to their place of origin and ethnicity.In northerners and southerners,the probabilities of RhD antigen mismatch in random blood transfusions,were 0.45%and 0.39%,respectively;The probabilities of RhCE antigen mismatch were antigen 26.31%and 23.60%,respectively;and the probability of RhCE antigen mismatch were 58.73 and 60.75 times higher than those of RhD antigen mismatch,respectively;DCCee is a high-risk phenotype for mismatching,accounting for 56.01%to 62.33%of all mismatching.A blood bank with about 100 donors can provide RhCE antigen-matched blood to 98%of Chinese patients.Conclusion In patients receiving RhD matched blood transfusions,the probability of RhCE antigen mismatch is approximately 25%.The establishment of a RhCE antigen matching strategy suitable for Chinese patients will help optimize individualized and precise blood transfusion.
作者
胡俊华
熊海玉
刘志伟
邵树军
田英
章白苓
王大方
余泽波
吴昌松
王新华
贾军会
辛文龙
胡海亮
岳丹
李军
陈静
朱培元
刘智勇
刘娟
马曙轩
陈善昌
颜小平
邵智利
张晓萍
倪文旭
马海梅
陈麟凤
黄远帅
霍彩虹
王岩
尚楠
杨舸
张芃
马婉茹
刘燕明
宫济武
赵桐茂
HU Junhua;XIONG Haiyu;LIU Zhiwei;SHAO Shujun;TIAN Ying;ZHANG Bailing;WANG Dafang;YU Zebo;WU Changsong;WANG Xinhua;JIA Junhui;XIN Wenlong;HU Hailiang;YUE Dan;LI Jun;CHEN Jing;ZHU Peiyuan;LIU Zhiyong;LIU Juan;MA Shuxuan;CHEN Shanchang;YAN Xiaoping;SHAO Zhili;ZHANG Xiaoping;NI Wenxu;MA Haimei;CHEN Linfeng;HUANG Yuanshuai;HUO Caihong;WANG Yan;SHANG Nan;YANG Ge;ZHANG Peng;MA Wanru;LIU Yanming;GONG Jiwu;ZHAO Tongmao(Department of Blood Transfusion,Beijing Hospital,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,National Center of Gerontology,Beijing 100730;Department of Blood Transfusion,Hunan Cancer Hospital,Changsha 410013;Department of Blood Transfusion,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310020;Department of Blood Transfusion,Henan Cancer Hospital,Zhengzhou 450008;Department of Blood Transfusion,The Eighth Affiliated Hospital of Southern Medical University,Foshan 528308;Department of Blood Transfusion,The Second Affiliated Hospital of Nanchang University,Nanchang 330006;Department of Blood Transfusion,Guangyuan Central Hospital,Guangyuan 628017;Department of Blood Transfusion,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016;Department of Blood Transfusion,The People's Hospital of Qiannan Buyi and Miao Autonomous Prefecture,Qiannan 558000;Department of Blood Transfusion,Aerospace Center Hospital,Beijing 100049;Department of Blood Transfusion,Guiyang Maternal and Child Healthcare Hospital(Guiyang Children's Hospital),Guiyang 550003;Department of Blood Transfusion,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Department of Blood Transfusion,Hanzhong Central Hospital,Hanzhong 723000;Department of Blood Transfusion,Chongqing General Hospital,Chongqing 401147;Department of Blood Transfusion,Hebei Medical University Third Hospital,Shijiazhuang 050051;Department of Blood Transfusion,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210000;Department of Blood Transfusion,Panzhihua Central Hospital,Panzhihua 617067;Department of Blood Transfusion,Dazhou Integrated Traditional Chinese and Western Medicine Hospital,Dazhou 635000;Department of Blood Transfusion,Beijing Children's Hospital,Capital Medical University,Beijing 100032;Department of Blood Transfusion,The People's Hospital of Hezhou City,Hezhou 542899;Department of Blood Transfusion,Zigong Third People's Hospital,Zigong 643020;Department of Blood Transfusion,Hebei Children's Hospital,Shijiazhuang 050031;Department of Blood Transfusion,Gansu Provincial Hospital,Lanzhou 734047;Department of Transfusion Medicine,General Hospital of Central Theater Command,Wuhan 430012;Department of Blood Transfusion,Beijing Tsinghua Changgung Hospital,Beijing 102218;Department of Blood Transfusion,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038;Department of Blood Transfusion,The Affiliated Hospital of Southwest Medical University,Luzhou 646000;Department of Blood Transfusion,Yulin Hospital the First Affiliated Hospital of Xi'an Jiaotong University,Yulin 719000;Department of Blood Transfusion,Yingkou Central Hospital,Yingkou 115000;Department of Blood Transfusion,Kaifeng Children's Hospital,Kaifeng 475000;Department of Transfusion Medicine,Zigong Maternal and Child Health Hospital,Zigong 643000;National Institutes of Health,Bethesda 20892 USA)
出处
《临床输血与检验》
2025年第6期767-774,共8页
Journal of Clinical Transfusion and Laboratory Medicine
