摘要
目的调查中国汉族患者人群中红细胞血型不规则抗体的检出率及各种特异性不规则抗体的分布特点.方法选取在我院就诊的来自中国不同行政区域汉族患者30800(男16563,女14237)例及孕妇4200例.采用微柱凝胶抗球蛋白技术筛查红细胞血型不规则抗体,对不规则抗体阳性者鉴定其抗体特异性、Ig类型,并检测其37℃的反应性.结果检出红细胞血型不规则抗体者共199例,占被调查人群的0.57%,其中男64例,占被调查男性的0.39%、女135例,占被调查女性的0.73%、孕妇44例占被调查孕妇的1.05%;IgM类抗体97例、IgG类抗体45例、IgM+IgG类抗体57例;37℃反应的温抗体89例,占被调查人群的0.25%;检出较多的特异性抗体依次为抗-M、抗-Lea、Rh系统抗体、抗-P1、抗-Leb、抗-JKa、抗-Fyb等.结论中国不同行政区域汉族患者红细胞血型不规则抗体检出率无统计学差异(χ2=12.20,P>0.05),但女性高于男性(χ2=18.46,P<0.0001),孕妇高于非孕女性患者(χ2=7.44,P<0.01);汉族患者人群红细胞血型不规则抗体检出率低于白种人;抗体特异性具有与白种人不同的分布特点,白种人中常见的抗-K在被检测的汉族患者中尚未发现,白种人中较常见的抗-Fya在汉族人中偶见;抗-D的检出率也明显低于白种人,并呈逐渐减少趋势.
AIM： To study the incidence and the distribution characteristics of irregular antibodies of erythrocyte blood group in 35 000 patients of Han nationality. METHODS ： 35 000 patients （ male 16 563, female 18 437, including pregnant women 4 200） selected from different administrative regions of China were detected for their erythrocyte irregular antibodies by Microcolum Gel Coomb＇s test. The positive patients of erythrocyte irregular antibodies were further identified with regards to the antibody specificity, Ig type and the reactions at 37℃. RESULTS： 199 out of 35 000 had irregular antibodies （ 0.57% ） , including 64 male cases （0.39%） and 135 female cases （0.73%） with 44 pregnant women （ 1.05% ） ; IgM type was found in 97 cases, IgG in 45, IgM ＋ IgG type in 57. And the warm antibody was seen in 89 cases, taking up 0.25% （89/35 000）. And the incidence of the specificity type from high to low were anti-M, anti-Le^a, Rh, anti- P1,anti-Le^b, anti-JK^a, anti-Fy^b, and so on. CONCLUSION： The incidence of erythrocyte irregular antibodies in Han population had no significant difference among different administrative regions in China（x^2 = 12. 20, P 〉0.05） ,but that of females was higher than that of males （ x^2 = 18.46, P 〈 0.0001 ）, and pregnant women higher than unpregnant women（ x^2 = 7.44, P 〈 0.01 ）.
出处
《第四军医大学学报》
北大核心
2007年第10期922-925,共4页
Journal of the Fourth Military Medical University
