摘要
目的观察水杨酸联合果酸对轻中度痤疮患者炎症因子及角质代谢的影响。方法选取2024年1月至2025年5月黄河三门峡医院收治的轻中度痤疮患者106例,按就诊顺序分为对照组(53例)与观察组(53例)。对照组使用20%果酸治疗(每2周治疗1次),观察组使用30%超分子水杨酸联合20%果酸治疗(2种药物间隔使用,每2周治疗1次),两组均治疗8周。比较两组临床疗效、炎症反应、角质代谢、生活质量及不良反应情况。结果观察组治疗总有效率较对照组高,差异有统计学意义(P<0.05)。治疗后,两组面部皮损处鳞屑中白细胞介素-6、白细胞介素-8及肿瘤坏死因子-α水平均降低,且观察组更低,差异有统计学意义(P<0.05)。治疗后,两组角质层水分含量均增大,经表皮水分流失量、皮脂分泌量及角质层厚度均减小,且观察组改善更明显,差异有统计学意义(P<0.05)。治疗后,两组痤疮患者特异性生活质量量表评分均升高,且观察组更高,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论轻中度痤疮患者采用水杨酸联合果酸治疗的效果确切,能有效减轻面部炎症反应,改善角质代谢,提高患者生活质量,且安全性良好。
Objective To observe the effects of salicylic acid combined with fruit acid on inflammatory factors and keratinocyte metabolism in patients with mild to moderate acne.Methods A total of 106 patients with mild to moderate acne admitted to Yellow River Sanmenxia Hospital from January 2024 to May 2025 were selected and divided into the control group(53 cases)and the observation group(53 cases)according to the order of visit.The control group was treated with fruit acid,while the observation group was treated with a combination of salicylic acid and fruit acid.Both groups were treated for 8 weeks.The clinical efficacy,inflammatory response,keratin metabolism,quality of life and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)in the scales of the facial lesions in both groups decreased,and the observation group was lower(P<0.05).After treatment,the water content of the stratum corneum(SCH)increased in both groups,while the transepidermal water loss(TEWL),sebum secretion,and stratum corneum thickness decreased.The improvement was more significant in the observation group(P<0.05).After treatment,the specific quality of life(Acne QOL)scores of both groups of acne patients increased,and the observation group was higher(P<0.05).There was no statistical significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of mild to moderate acne patients with salicylic acid combined with fruit acid has a definite effect,which can effectively reduce facial inflammatory reactions,improve keratinocyte metabolism,enhance patients'quality of life,and has good safety.
作者
汤腾雁
郑永青
TANG Tengyan;ZHENG Yongqing(Department of Dermatology and Medical Aesthetics,Yellow River Sanmenxia Hospital,Sanmenxia 472000,Henan Province,China)
出处
《中国医疗美容》
2025年第11期26-31,共6页
China Medical Cosmetology
关键词
痤疮
水杨酸
果酸
炎症
角质代谢
flacne
salicylic acid
fruit acid
inflammation
keratinocyte metabolism
