摘要
目的:探究面部轻中度痤疮应用口服盐酸米诺环素胶囊联合强脉冲光(Intense pulsed light,IPL)的治疗效果。方法:纳入2022年7月-2023年7月在笔者医院治疗的面部轻中度痤疮患者102例,采用抽签法分为两组,对照组(n=51,采用IPL治疗),观察组(n=51,采用IPL+口服盐酸米诺环素胶囊治疗),比较两组临床疗效和不良反应,比较两组治疗前后白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平、角质层含水量、皮脂分泌量。结果:观察组总有效率高于对照组(P<0.05);治疗后,与对照组相比,观察组IL-6、TNF-α水平更低,观察组角质层含水量更多,皮脂分泌量更少(P<0.05);两组不良反应总发生率差异无统计学意义(P>0.05)。结论:IPL联合盐酸米诺环素胶囊治疗能够减轻面部轻中度痤疮患者的炎症反应,增加患者角质层含水量,减少皮脂分泌,临床疗效显著,同时具有安全性。
Objective To explore the therapeutic effect of minocycline hydrochloride+intense pulsed light(IPL)on mild-to-moderate facial acne.Methods Totally 102 patients with mild-to-moderate facial acne in the hospital were included from July 2022 to July 2023,They were divided into two groups by drawing lots.The control group(n=51,IPL treatment)and observation group(n=51,IPL+minocycline hydrochloride).The clinical eficacy and adverse reactions as well as levels of interleukin-6(IL-6)and tumor necrosis factor-a(TNF-a),stratum corneum water content and sebum secretion before and after treatment were compared between groups.Results The observation group had higher total effective rate than the control group(P<0.05).After treatment,compared with the control group,the levels of IL-6 and TNF-a in the observation group were lower,the water content of stratum corneum was more while the sebum secretion was less(P<0.05).There was no obvious difference in the total incidence rate of adverse reactions between both groups(P>0.05).Conclusion IPL combined with minocycline hydrochloride can relieve the inflammatory response of patients with mild-to-moderate facial acne,increase the water content of the stratum corneum,and reduce the sebum secretion.In addition,it has significant clinical efficacy and safety.
作者
高琳
孙晓飞
陆丽丽
GAO Lin;SUN Xiaofei;LU Lili(Department of Photomedicine,Shanghai Hospital of Dermatology,Shanghai 200443,China)
出处
《中国美容医学》
2025年第6期108-111,共4页
Chinese Journal of Aesthetic Medicine
关键词
强脉冲光
盐酸米诺环素
轻中度痤疮
角质层含水量
intense pulsed light
minocycline hydrochloride
mild-to-moderate acne
water content of stratum corneum
