摘要
肠道菌群作为人体最复杂的微生态系统,其通过“肠-肺轴”这一双向通道途径,与远端肺部免疫稳态和炎症反应发生相互作用。近年来发现,活动性肺结核(APTB)患者肠道菌群显著失调。菌群紊乱可通过削弱宿主抗结核免疫、加剧肺部过度炎症反应等方式参与疾病的发生发展。在治疗方面,以肠道菌群为靶点的干预策略,补充特定益生菌、合生元,实施高膳食纤维饮食等,在辅助抗结核治疗中展现出一定潜力。未来研究应聚焦于阐释肠道菌群在APTB发病中的作用,并推动基于菌群特征的个体化微生态干预策略向临床应用转化。
As the most complex microecosystem in the human body,intestinal flora closely interacts with the immune homeostasis and inflammatory response of the distal lung through the bidirectional channel of the"gut-lung axis".In recent years,it has been found that patients with active pulmonary tuberculosis(APTB)have significantly unbalanced intestinal flora.Disorders of flora can participate in the occurrence and development of the diseases by weakening the host's anti tuberculosis immunity and exacerbating excessive inflammatory responses in the lungs.In terms of treatment,intervention strategies targeting intestinal flora,supplementing specific probiotics and synbiotics,and implementing a high-dietary fiber diet have shown certain potential in the adjuvant anti-tuberculosis treatment.Future research should focus on explaining the role of intestinal flora in the pathogenesis of APTBand promoting the transformation of individualized microecological interven tion strategies based on flora characteristics into clinical application.
作者
木叶斯尔·买买提
戴月梅
Muyesier·Maimaiti;DAI Yuemei(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《医学综述》
2025年第21期2663-2666,2673,共5页
Medical Recapitulate
关键词
活动性肺结核:肠道菌群:肠-肺轴
微生态失调
Active pulmonary tuberculosis
Intestinal flora
Gut-lung axis
Microecological imbalance
