摘要
核因子κB(NF-κB)是细胞内的重要转录因子,广泛参与免疫应答、炎症反应、细胞增殖和凋亡等过程。在多种肝脏疾病中,如慢性肝炎、肝纤维化、肝硬化、肝癌等,NF-κB信号通路的异常激活扮演了关键角色。大量研究表明,抑制NF-κB活性可能有效减少炎症和纤维化,改善代谢紊乱。多种天然药物(如苦参碱、丹酚酸B等)具有抑制NF-κB发挥抗炎、抗纤维化和抗肿瘤作用的潜力。本文探讨了NF-κB信号通路在多种肝脏疾病中的关键作用及作为治疗靶点的潜力,突出其作为肝脏疾病治疗靶点的潜能,为肝脏疾病治疗开辟新的方向。
Nuclear factor-kappa B(NF-κB)is an important intracellular transcription factor widely involved in the processes such as immune response,inflammatory response,cell proliferation,and apoptosis.The abnormal activation of the NF-κB signaling pathway plays a pivotal role in various liver diseases including chronic hepatitis,liver fibrosis,liver cirrhosis,and hepatocellular carcinoma.Extensive studies have shown that inhibiting NF-κB activity may effectively reduce inflammation and fibrosis and improve metabolic disorders.Several natural compounds,such as matrine and salvianolic acid B,have shown the potential in suppressing NF-κB activity,thereby exerting anti-inflammatory,anti-fibrotic,and anti-tumor effects.This article systematically reviews the critical role of the NF-κB signaling pathway in liver diseases and its potential as a therapeutic target,in order to highlight its potential as a therapeutic target for liver diseases and provide new directions for the treatment of liver diseases.
作者
冯雯倩
杜洋
毛德文
陈玮钰
付蕾
颜璐怡
姚春
蓝艳梅
FENG Wenqian;DU Yang;MAO Dewen;CHEN Weiyu;FU Lei;YAN Luyi;YAO Chun;LAN Yanmei(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Laboratory of Molecular Biology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《临床肝胆病杂志》
北大核心
2025年第9期1949-1955,共7页
Journal of Clinical Hepatology
基金
国家自然科学基金(82260899)
国家自然科学基金联合基金项目重点支持项目(U23A20521)
广西科技重大专项(桂科AA23023035)
高水平中医药重点学科建设项目-中医内科学(zyyzdxk-2023166)
广西研究生教育创新计划(YCSW2024407)
姚春桂派中医大师传承工作室(GZY2024002)
中医学广西一流学科(桂教科研〔2022〕1号)。
