摘要
慢性炎症是诱发动脉粥样硬化、高血压、心肌梗死等心血管疾病的重要原因之一。炎症因子如IL-6、TNF-α、IL-1β等均能导致心肌肥大、心肌纤维化和血管平滑肌细胞异常增殖。茶叶中富含的多种特征性化合物如茶多酚、茶氨酸、茶黄素、咖啡碱等,它们通过抑制重要炎症介质的产生和调控NF-κB、MAPK、Tolls样受体等信号通路,抑制心血管炎症的发生及发展,对心血管疾病具有预防和治疗作用。本文综述了近几年茶叶中的茶多酚、茶氨酸、茶黄素等特征成分通过抑制心血管炎症预防心血管疾病的作用及其机制的研究进展。
Chronic inflammation is one of the important causes of cardiovascular diseases such as atherosclerosis,hypertension and myocardial infarction.Inflammatory factors such as IL-6,TNF-αand IL-1βcan induce many cardiovascular diseases,including myocardial hypertrophy,myocardial fibrosis and abnormal proliferation of vascular smooth muscle cells.Tea is rich in characteristic compounds.These compounds play preventive and therapeutic roles for cardiovascular diseases by inhibiting proinflammatory cytokines production,and regulating the signal pathways such as NF-κB,MAPK and Tolls-like receptors.In this review,we summarized the recent advance of the main characteristic compounds in tea on preventing inflammation related cardiovascular diseases.
作者
姚敏
李大祥
谢忠稳
YAO Min;LI Daxiang;XIE Zhongwen(State Key Laboratory of Tea Plant Biology and Utilization.Anhui Agricultural University,Hefei 230036,China)
出处
《茶叶科学》
CAS
CSCD
北大核心
2020年第1期1-14,共14页
Journal of Tea Science
基金
国家自然科学基金(31571207)
安徽省高等学校自然科学重大项目(KJ015ZD22)
关键词
心血管炎症
茶多酚
信号通路
特征性化合物
cardiovascular inflammation
tea polyphenols
signaling pathways
characteristic compounds
