摘要
肝纤维化是慢性肝损伤后组织修复过程中的代偿反应,也是诸多慢性肝病发展必经的病理过程。在病理状态下,肝脏氧化系统与抗氧化系统失衡,造成活性氧/活性氮产生过多或清除不足,诱导肝细胞损伤,扩大炎症反应,促进肝纤维化的发生发展。NF-κB作为炎症反应和氧化应激的主调控器,在肝纤维化进程中发挥关键作用。因此,活性氧/活性氮与NF-κB信号通路的级联交互关系对于进一步阐明肝纤维化的发病机制,探索有效的防治策略起到重要的指导作用。本文即对两者之间的交互关系及在肝纤维化进程中的重要作用进行综述和讨论,以期为肝纤维化的靶向治疗提供策略和参考。
Liver fibrosis is a compensatory response in the process of tissue repair after chronic liver injury,and it is also a necessary pathological process in the progression of a variety of chronic liver diseases.In the pathological state,the imbalance between hepatic oxidative system and antioxidant system can lead to the excessive production or insufficient clearance of reactive oxygen species(ROS)/reactive nitrogen species(RNS),which may induce the injury of hepatocytes,expand inflammatory response,and promote the development and progression of liver fibrosis.As a master regulator of oxidative stress and inflammatory response,NF-κB plays a key role in the process of liver fibrosis.Therefore,the cascade interaction between ROS/RNS and the NF-κB signaling pathway plays a guiding role in further clarifying the pathogenesis of liver fibrosis and exploring effective prevention and treatment strategies.This article reviews and discusses the interaction between ROS/RNS and the NF-κB signaling pathway and its important role in the progression of liver fibrosis,so as to provide strategies and references for targeted therapy for liver fibrosis.
作者
闵远骞
李姗
刘湘花
杨艺
李宁宁
禄保平
MIN Yuanqian;LI Shan;LIU Xianghua;YANG Yi;LI Ningning;LU Baoping(The Second Clinical Medical School,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Institute of Hepatology,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Medical College,Zhengzhou 451191,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第6期1454-1460,共7页
Journal of Clinical Hepatology
基金
河南省中医药科学研究专项(2022ZY1167)
河南省高等学校青年骨干教师培养计划(2021GGJS084)
河南省高等学校重点科研项目(21B310003)。
关键词
肝纤维化
氧化性应激
活性氧
活性氮
NF-ΚB
Liver Fibrosis
Oxidative Stress
Reactive Oxygen Species
Reactive Nitrogen Species
NF-kappa B
