摘要
目的探讨血清免疫球蛋白G4(IgG4)、γ-谷氨酰转肽酶(γ-GT)联合对自身免疫性胰腺炎(AIP)的鉴别诊断价值分析。方法选取2023年6月至2024年12月我院收治并确诊的AIP患者62例(AIP组)与胰腺癌患者62例(胰腺癌组),以及同期来院体检的健康者62例(健康组)。结果较胰腺癌组而言,AIP组IgG4、γ-GT水平更低,较健康组而言,AIP组IgG4、γ-GT水平更高(P<0.05)。较Ⅲ期患者而言,胰腺癌Ⅱ期患者IgG4、γ-GT水平更低,较Ⅰ期患者而言,Ⅱ期组IgG4、γ-GT水平更高(P<0.05)。多因素logistic回归分析显示IgG4、γ-GT水平是AIP发病影响因素(P<0.05)。血清IgG4、γ-GT水平在AIP中呈正相关(P<0.05);血清IgG4、γ-GT单独诊断及联合诊断AIP的曲线下面积(AUC)分别为0.908、0.820、0.926,敏感度、特异度分别为80.6%/90.3%、95.2%/58.1%、85.5%/88.7%。结论血清IgG4、γ-GT的检测对于AIP的诊断鉴别临床参考价值,且将IgG4、γ-GT联合应用有助于提高AIP的诊断效能。
Objective To analyze the value of combined serum immunoglobulin G4(IgG4)and γ-glutamyl transpeptidase(γ-GT)in the differential diagnosis of autoimmune pancreatitis(AIP).Methods A total of 62 patients with AIP(AIP group)and 62 patients with pancreatic cancer(pancreatic cancer group)admitted and diagnosed in our hospital from June 2023 to December 2024 were selected,as well as 62 healthy patients(healthy group)who came to our hospital for physical examination during the same period.Results Compared with the pancreatic cancer group,the levels of IgG4 and γ-GT in the AIP group were lower,while compared with the healthy group,the levels of IgG4 and γ-GT in the AIP group were higher.The differences were statistically significant(P<0.05).Compared with patients in phase Ⅲ,patients in phase Ⅱ of pancreatic cancer have lower levels of IgG4 and γ-GT,and patients in phaseⅡhave higher levels of IgG4 and γ-GT than patients in phaseⅠ(P<0.05).Multivariate logistic regression analysis showed IgG4 and γ-GT were influencing factors for the onset of AIP.(P<0.05).The levels of serum IgG4 and γ-GT were positively correlated in AIP(P<0.05).The area under the curve(AUC)for the diagnosis of AIP using serum IgG4 and γ-GT alone and in combination were 0.908,0.820,and 0.926,respectively.The sensitivity and specificity were 80.6%/90.3%,95.2%/58.1%,and 85.5%/88.7%,respectively.Conclusion The detection of serum IgG4 and γ-GT has clinical reference value for the diagnosis and differentiation of AIP,and the combined application of IgG4 and γ-GT can help improve the diagnostic efficiency of AIP.
作者
刘华
李金梅
李雨珊
LIU Hua;LI Jinmei;LI Yushan(Department of Clinical Laboratory,Gaoping District People's Hospital of Nanchong,Nanchong,Sichuan,637100,China;Department of Clinical Laboratory,Beijing Anzhen Hospital Affiliated to Capital Medical University Nanchong Hospital(Nanchong Central Hospital),Nanchong,Sichuan 637000,China)
出处
《分子诊断与治疗杂志》
2025年第10期1939-1942,共4页
Journal of Molecular Diagnostics and Therapy
基金
南充市校合作科研专项项目(18SXHZ0513)。
