摘要
药物相关性颌骨坏死(MRONJ)已成为抗骨吸收药物和抗血管生成药物的并发症,近年来这一问题备受关注。对种植患者而言,严重的MRONJ可以对颌骨产生严重后果且缺乏有效的预防策略。近年来,关于MRONJ有大量的文献报告,但其缺乏系统性。因此,本文将从MRONJ的定义、发病率、病因和发病机制、分期和诊断标准、组织病理学表现、风险因素、预防和治疗策略等方面进行讨论,并探讨种植体周MRONJ(PI-MRONJ)的风险与应对方法。目前MRONJ的很多方面存在分歧和争议,希望本文的客观论述能为临床医生展现目前的研究进展,为预防和治疗MRONJ和PI-MRONJ提供参考。
Medication-related osteonecrosis of the jaw(MRONJ)has emerged as a serious complication associated with antiresorptive therapy and anti-angiogenic therapy,and has received increasing attention in recent years.In implant patients,severe MRONJ can lead to devastating consequences for the jawbone,with few effective preventive strategies currently available.Although a substantial body of literature on MRONJ exists,it often lacks systematic organization.Therefore,this review discusses the definition,incidence,etiology and pathogenesis,staging,diagnostic criteria,histopathological manifestations,risk factors,prevention,and treatment strategies for MRONJ.Special emphasis is placed on the risks and management of peri-implant MRONJ(PI-MRONJ).Despite the lack of consensus on many aspects of MRONJ,the objective discussion in this article presents current research progress to clinicians and provide references for the prevention and treatment of MRONJ and PI-MRONJ.
作者
宿玉成
Su Yucheng(Dental Implant Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing Implant Training College(BITC),Beijing 100032,China)
出处
《中国口腔种植学杂志》
2025年第4期317-330,共14页
Chinese Journal of Oral Implantology
关键词
抗骨吸收药物
抗血管生成药物
药物相关性颌骨坏死
种植体周药物相关性颌骨坏死
Antiresorptive drugs
Anti-angiogenic drugs
Medication-related osteonecrosis of the jaw(MRONJ)
Peri-implant medication-related osteonecrosis of the jaw(PI-MRONJ)
