摘要
多发性骨髓瘤骨病(MBD)作为多发性骨髓瘤的常见并发症,发病率逐年升高,其引发的骨骼相关事件(SREs)影响患者生活质量及预后。西医治疗以抗骨吸收药物为主,虽可降低SREs发生风险,但对已形成的骨损伤修复能力不足,且长期用药并发症多。中医药治疗基于MBD“肾虚为本,瘀毒为标”的病机,以补肾法为主要治疗原则,通过多靶点干预骨代谢调节网络及表观遗传学机制,在缓解骨痛、改善溶骨病灶及控制肿瘤负荷方面具有优势。未来需结合现代技术深化机制研究,推动中西医协同方案的个体化应用,以改善MBD患者预后。
As a common complication of multiple myeloma,multiple myeloma bone disease(MBD)sees an increasing incidence year by year.The skeletal-related events(SREs)caused by MBD affect the quality of life and prognosis of the patients.Western medicine treatment mainly uses anti-bone resorption drugs,which can reduce the risk of SREs,but have insufficient ability to repair existing bone injuries,and have many complications after long-term medication.Based on the pathogenesis of MBD,which is"renal deficiency as the root,stasis and toxin as the tip",traditional Chinese medicine(TCM)treatment has advantages in relieving bone pain,improving osteolytic lesions and controlling tumor burden through multi-target intervention of bone metabolism regulatory network and epigenetic mechanism.In the future,it is necessary to combine modern technology to deepen the research on the mechanisms and promote the individualized application of collaborative programs between TCM and western medicine,in order to improve the prognosis of MBD patients.
作者
谢黎娜
秦兰
XIE Lina;QIN Lan(The Fourth Clinical Medicine College of Xinjiang Medical University,Urumqi 830000,China;Department of Hematology,Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830000,China)
出处
《医学综述》
2025年第17期2132-2138,共7页
Medical Recapitulate
关键词
多发性骨髓瘤骨病
中医药治疗
多靶点干预
骨代谢调节
骨骼相关事件
Multiple myeloma bone disease
Traditional Chinese medicine treatment
Multi-target intervention
Bone metabolism regulation
Skeletal-related events
