摘要
肝细胞癌(hepatocellular carcinoma,HCC)的发病率在全球范围内呈现不断上升的趋势。尽管HCC的总体治愈率相对较高,但手术切除后的5年内复发率为50%~70%。值得注意的是,早期复发通常更具侵袭性,并导致更差的预后。在肿瘤的发生与发展进程中,免疫反应与炎症反应扮演着至关重要的角色。众多研究已表明,外周血中特定炎性细胞的计数及其比例,例如血小板、中性粒细胞、淋巴细胞、单核细胞等,构成了恶性肿瘤预后评估的关键指标。本文的核心目的在于全面概述外周血清中的NLR、PLR、SII、LMR以及CRP在HCC领域的最新应用进展,旨在为临床实践提供有益的参考依据。
The incidence of hepatocellular carcinoma(HCC)has been steadily increasing worldwide.Although the overall cure rate for HCC is relatively high,the recurrence rate within five years following surgical resection can reach as high as 50%-70%.Notably,early recurrence tends to be more aggressive and is associated with a poorer prognosis.Both immune response and inflammatory response play crucial roles in tumor development and progression.Numerous studies have shown that the counts and ratios of specific inflammatory cells in peripheral blood—such as platelets,neutrophils,lymphocytes,and monocytes—serve as key indicators for assessing malignancy prognosis.The primary aim of this article was to provide a comprehensive review of the latest advancements in the application of NLR,PLR,SII,LMR and CRP in the context of HCC,aiming to offer valuable references for clinical practice.
作者
武林得
涂勇浪
徐自丽
李刚
WU Linde;TU Yonglang;XU Zili;LI Gang(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Kunming Medical University,Kunming 650000;Department of General Surgery,Yunnan Maternal and Child Health Care Hospital,China)
出处
《胃肠病学和肝病学杂志》
2025年第9期1384-1389,共6页
Chinese Journal of Gastroenterology and Hepatology
