摘要
目的探讨外周血淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))及系统性炎症指数[血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)]与骨折患者发生医院感染风险的相关性。方法选取2021年8月至2022年10月在我院骨科住院治疗的157例骨折患者,根据术后感染诊断标准将其分为感染组(22例)和非感染组(135例);同时选取41名健康体检人群作为对照组。检测并比较三组的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、PLR、NLR及LMR。采用二分类Logistic回归模型分析骨折患者发生医院感染的影响因素。结果感染组的CD4^(+)、CD4^(+)/CD8^(+)低于非感染组和对照组,CD8^(+)高于非感染组和对照组,差异具有统计学意义(P<0.05)。感染组的PLR、NLR高于非感染组和对照组,LMR低于非感染组和对照组,差异具有统计学意义(P<0.05)。二分类Logistic回归分析结果显示,CD4^(+)降低、CD8^(+)升高、CD4^(+)/CD8^(+)降低、PLR升高、NLR升高和LMR降低是骨折患者发生医院感染的危险因素(P<0.05)。结论CD4^(+)、CD4^(+)/CD8^(+)、LMR降低及CD8^(+)、PLR、NLR升高与骨折患者医院感染风险增加相关。
Objective To investigate the correlation between peripheral blood lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))and systemic inflammation indexes[platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR)]and the risk of nosocomial infection in patients with fracture.Methods A total of 157 fracture patients who were hospitalized in the orthopedics department of our hospital from August 2021 to October 2022 were selected and divided into infection group(22 cases)and non-infection group(135 cases)according to the diagnostic criteria of postoperative infection;at the same time,41 healthy people were selected as control group.CD4^(+),CD8^(+),CD4^(+)/CD8^(+),PLR,NLR and LMR were detected and compared among the three groups.Binary Logistic regression model was used to analyze the influencing factors of nosocomial infection in fracture patients.Results The CD4^(+)and CD4^(+)/CD8^(+)in the infected group were lower than those in the non-infected group and the control group,the CD8^(+)was higher than that in the non-infected group and the control group,and the differences were statistically significant(P<0.05).The PLR and NLR of the infected group were higher than those of the non-infected group and the control group,the LMR was lower than that of the non-infected group and the control group,and the differences were statistically significant(P<0.05).Binary Logistic regression analysis results showed that decreased CD4^(+),increased CD8^(+),decreased CD4^(+)/CD8^(+),increased PLR,increased NLR and decreased LMR were risk factors for nosocomial infection in fracture patients(P<0.05).Conclusion The decrease of CD4^(+),CD4^(+)/CD8^(+),LMR and the increase of CD8^(+),PLR and NLR are associated with the increased risk of nosocomial infection in patients with fracture.
作者
周跃
李莹
朱勇
陶运娟
ZHOU Yue;LI Ying;ZHU Yong;TAO Yunjuan(Laboratory Department,Yancheng Hospital of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Yancheng 224001,China;Traditional Chinese Medicine Surgery Department,Yancheng Hospital of Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Yancheng 224001,China)
出处
《临床医学研究与实践》
2025年第25期46-49,共4页
Clinical Research and Practice
关键词
淋巴细胞亚群
系统性炎症指数
骨折
医院感染
lymphocyte subsets
systemic inflammation index
fracture
nosocomial infection
