摘要
目的探讨急性胰腺炎患者早期短时间床旁血液净化的治疗作用。方法选取2021年4月—2023年4月中国人民解放军联勤保障部队第九一〇医院消化内科70例急性胰腺炎患者为研究对象,随机分为观察组与对照组,各35例。观察组采用早期短时间床旁血液净化治疗,对照组采用常规治疗。比较2组患者的胃肠功能[胃泌素(gastrin,GAS)、胃动素(motilin,MOT)、血管活性肠肽(vasoactive intestinal peptide,VIP)]、炎症反应[白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)]、临床指标及治疗效果。结果观察组治疗后GAS为(130.19±10.25)μmol/L、VIP为(5.14±1.15)μmol/L,均低于对照组的(183.38±10.36)μmol/L、(6.49±1.22)μmol/L;观察组MOT为(226.41±10.16)ng/L,高于对照组的(173.60±10.25)ng/L,差异有统计学意义(P<0.001)。观察组治疗后PCT为(6.48±1.14)μg/L、IL-6为(32.55±2.14)μg/mL、CRP为(5.70±1.25)mg/L,均低于对照组的(8.33±2.22)μg/L、(38.29±2.16)μg/mL、(8.22±1.30)mg/L,差异有统计学意义(P<0.001)。观察组肠蠕动恢复时间为(2.22±0.17)d、体温恢复时间为(1.75±0.23)d、腹痛缓解时间为(1.71±0.21)d、血淀粉酶恢复正常时间为(5.07±0.33)d、肠鸣音恢复时间为(3.46±0.19)d、住院时间为(14.41±2.16)d,均短于对照组的(4.69±0.20)d、(3.59±1.05)d、(3.86±0.15)d、(6.59±1.20)d、(5.17±0.24)d、(18.36±2.30)d,差异有统计学意义(P<0.001)。观察组治疗总有效率为97.14%,高于对照组的80.00%,差异有统计学意义(P<0.05)。结论早期短时间床旁血液净化治疗急性胰腺炎患者效果良好,可改善其胃肠功能,减轻机体炎症反应,促进疾病快速恢复。
Objective To explore the therapeutic effect of early short time bedside blood purification in patients with acute pancreatitis.Methods A total of 70 patients with acute pancreatitis in the department of gastroenterology,the 910th Hospital of the Joint Logistic Support Force of the People′s Liberation Army of China from April 2021 to April 2023 were selected as the research objects and randomly divided into the observation group and the control group,with 35 cases in each group.The observation group adopted early short-term bedside blood purification treatment,the control group adopted conventional treatment.The gastrointestinal functions[gastrin(GAS),motilin(MOT),vasoactive intestinal peptide(VIP)]and inflammatory responses[(interleukin-6,IL-6),Creactive protein(CRP),procalcitonin(PCT)],clinical indicators and therapeutic effects were compared between the two groups.Results After treatment,the GAS and VIP levels in the observation group were(130.19±10.25)μmol/L and(5.14±1.15)μmol/L,respectively,which were lower than those in the control group(183.38±10.36)μmol/L and(6.49±1.22)μmol/L,respectively.The MOT of the observation group was(226.41±10.16)ng/L,which was higher than that(173.60±10.25)ng/L of the control group,and the difference was statistically significant(P<0.001).After treatment,the PCT was(6.48±1.14)μg/L,IL-6 was(32.55±2.14)μg/mL,and CRP was(5.70±1.25)mg/L in the observation group,which were all lower than those(8.33±2.22)μg/L,(38.29±2.16)μg/mL,and(8.22±1.30)mg/L of the control group,the differences were statistically significant(P<0.001).The recovery time of intestinal peristalsis in the observation group was(2.22±0.17)days,the recovery time of body temperature was(1.75±0.23)days,the relief time of abdominal pain was(1.71±0.21)days,the time for blood amylase to return to normal was(5.07±0.33)days,the recovery time of bowel sounds was(3.46±0.19)days,and the hospital stay was(14.41±2.16)days,which were shorter than[(4.69±0.20)days,(3.59±1.05)days,(3.86±0.15)days,(6.59±1.20)days,(5.17±0.24)days,(18.36±2.30)days]of the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was 97.14%,which was higher than the control group's 80.00%,and the difference was statistically significant(P<0.05).Conclusion Early short time bedside blood purification is effective in the treatment of acute pancreatitis,which can improve the gastrointestinal function,reduce the inflammatory response and promote the rapid recovery of the disease.
作者
陈旭东
苏雅青
吴美玉
林艺
郑媛媛
陈建兴
黄永德
CHEN Xudong;SU Yaqing;WU Meiyu;LIN Yi;ZHENG Yuanyuan;CHEN Jianxing;HUANG Yongde(Department of Gastroenterology,the 910th Hospital of the Joint Logistic Support Force of the People′s Liberation Army,Quanzhou Fujian 362000,China)
出处
《中国卫生标准管理》
2025年第11期112-115,共4页
China Health Standard Management
关键词
急性胰腺炎
炎症反应
治疗效果
床旁血液净化治疗
胃肠功能
C反应蛋白
acute pancreatitis
inflammatory response
therapeutic effect
bedside blood purification treatment
gastrointestinal function
C-reactive protein
