摘要
目的:探究连续性床旁血液滤过与血液灌流联用对急诊急性有机磷农药中毒(AOPP)患者恢复进程、预后的影响。方法:选取2023年1月—2024年4月太仓市第一人民医院收治的98例急诊AOPP患者作为研究对象,根据不同治疗方法将其分为两组,每组各49例。两组均行常规治疗,对照组采取血液灌流治疗,观察组在对照组基础上联合连续性床旁血液滤过治疗。比较两组治愈率、心肌损伤指标、肝功能、炎性因子及并发症。结果:治疗后,观察组治愈率高于对照组,胆碱酯酶水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、乳酸脱氢酶(LD)、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:对急诊AOPP患者使用连续性床旁血液滤过与血液灌流联合治疗,效果确切,可减轻炎症反应、改善心肌损伤指标及肝功能,治愈率高,并发症少,安全可靠。
Objective:To explore the influence of continuous bedside blood frltration combined with hemoperfusion on the recovery process and prognosis of emergency patients with acute organophosphorus pesticide poisoning(AOPP).Method:A total of 98 patients with emergency AOPP admitted to the First People's Hospital of Taicang City from January 2023 to April 2024 were selected as the research subjects.They were divided into two groups according to different treatment methods,with 49 cases in each group.Both groups received conventional treatment.The control group was treated with hemoperfusion,while the observation group was treated with continuous bedside hemofiltration on the basis of the control group.The cure rate,myocardial injury indicators,liver function,inflammatory factors and complications of the two groups were compared.Result:After the treatment,the cure rate of the observation group was higher than that of the control group,and the cholinesterase level was also higher than that of the control group,the differenre was statistically significant(P<0.05).After the treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatine kinase(CK),lactate dehydrogenase(LD),interleukin-8(IL-8),highsensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were lower than those in the control group,the differenre was statistically significant(P<0.05).After the treatment,the incidence of complications was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:The combined treatment of continuous bedside hemofiltration and hemoperfusion for emergency patients with AOPP has a definite effect.It can reduce inflammatory responses,improve myocardial injury indicators and liver function,has a high cure rate,few complications,and is safe and reliable.
作者
汤文夏
TANG Wenxia(Taicang First People's Hospital,Taicang 215400,China)
出处
《中外医学研究》
2025年第20期51-54,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
急诊
急性有机磷农药中毒
连续性床旁血液滤过
血液灌流
恢复进程
预后
Emergency department
Acute organophosphate pesticide poisoning
Continuous bedside blood filtration
Blood perfusion
Recovery process
Prognosis
