摘要
泄泻是消化系统疾病最常见的症状之一,其发病率逐年增高。多数泄泻不危及生命,却给患者带来极大的痛苦,因此泄泻的治疗一直是临床研究的热点。“利小便以实大便”是中医常用的一种治疗泄泻的方法,即分消走泄,使水走膀胱,达到“小便利,大便实,泄泻止”的目的。现代医学则认为泄泻的治疗应及时补充电解质,因为“利小便”会引起脱水等不良反应。微生态学的发展,为中西医之间的理论和实践交流提供了新途径,促进了中医药微生态学的产生和发展。因此,本文针对中医“利小便以实大便”治法,基于肠道菌群及其代谢产物探讨肠黏膜屏障、膜转运蛋白、肾-肠轴与水液代谢的关系,阐释该治法的微生态学和生物医学基础,丰富中医药微生态学的研究。
Diarrhea is one of the most common symptoms of digestive system diseases,and its morbidity gradually increases.Although diarrhea rarely endangers patients'lives,it brings great pain to the patients,so the treatment of diarrhea has always been a hot topic in clinical research."Promoting urination to regulate bowel movements"is a common treatment method in traditional Chinese medicine(TCM)for treatment of watery diarrhea by excreting water through the bladder to achieve the results of"urination promoted,stool thickened,diarrhea stopped".However,modern medicine believes that watery diarrhea should be treated with timely electrolytes supplementation,and promoting urination can cause adverse reactions such as dehydration.The development of microecology has provided a new approach for theoretical and practical communication between TCM and Western medicine,and promoted the emergence and development of TCM microecology.This paper aims at the TCM treatment method of"promoting urination to regulate bowel movements",discusses the relationship among the intestinal mucosal barrier,membrane carriers,kidney-gut axis and water metabolism based on intestinal microbiota and their metabolites,and elucidates the microbiological and biomedical basis of this treatment.
作者
余东霖
张霜雪
田强红
王梓羽
崔志钊
蔡莹
YU Donglin;ZHANG Shuangxue;TIAN Qianghong;WANG Ziyu;CUI Zhizhao;CAI Ying(School of Traditional Chinese Medicine,Hu'nan University of Chinese Medicine,Changsha,Hu'nan 410208,China;不详)
出处
《中国微生态学杂志》
北大核心
2025年第6期727-734,共8页
Chinese Journal of Microecology
基金
湖南中医药大学研究生创新课题(2024CX148)
湖南省教育厅科学研究重点项目(24A0281)
湖南省大学生创新创业训练计划项目(S202410541013)。
关键词
中医药
微生态
泄泻
利小便以实大便
肠黏膜屏障
膜转运蛋白
肾-肠轴
Traditional Chinese medicine
Microecology
Diarrhea
Promoting urination to regulate bowel movements
Intestinal mucosal barrier
Membrane transporters
Kidney-gut axis
