摘要
动脉粥样硬化作为多种心脑血管疾病的病理基础,仍然是全球死亡的主要原因。目前,越来越多的证据表明肠道菌群及其代谢产物是动脉粥样硬化的重要发病机制。“肝与大肠相通”是中医基础理论对肝与肠道紧密联系的高度概括,与现代医学“肠肝轴”理论相契合。通过阐述“肝与大肠相通”的中医理论源流、肝-肠道菌群-动脉粥样硬化三者之间的关系及以肝肠轴调控肠道菌群稳态作为中医药防治动脉粥样硬化的作用靶点等方面,从微生态学的角度阐明从肝论治动脉粥样硬化的现实意义,以期为临床上进一步深入研究和诊疗动脉粥样硬化提供新的视角。
Atherosclerosis,as the pathological basis of many cardiovascular and cerebrovascular diseases,is still the main cause of global death.At present,more and more evidence shows that gut microbiota and its metabolites are the important pathogenesis of atherosclerosis.“The connection between liver and large intestine”is a high generalization of the close relationship between liver and intestinal tract in the basic theory of traditional Chinese medicine,which is consistent with the theory of“gut-liver axis”in modern medicine.By expounding the origin of traditional Chinese medicine theory of“the connection between liver and large intestine”,the relationship among liver-gut microbiota-atherosclerosis,and taking the regulation of gut microbiota homeostasis by gut-liver axis as the target of traditional Chinese medicine prevention and treatment of atherosclerosis,this paper expounded the practical significance of treating atherosclerosis from the perspective of microecology,in order to provide a new perspective for further clinical research and diagnosis and treatment of atherosclerosis.
作者
黄浪浪
刘中勇
刘言薇
HUANG Langlang;LIU Zhongyong;LIU Yanwei(Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,Jiangxi,China;Jiangxi University of Chinese Medicine,Nanchang 330004,Jiangxi,China;National Engineering Research Center for Solid Preparation Technology of Traditional Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,Jiangxi,China)
出处
《辽宁中医杂志》
北大核心
2025年第8期29-32,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82460914,82260918)
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023113)
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)
江西省自然科学基金项目(20242BAB20439,20232BAB206146)
江西省卫生健康委科技计划项目(202410045)
江西中医药大学重点学科建设经费(2023jzzdxk033)。
关键词
肝与大肠相通
肠道菌群
动脉粥样硬化
肝肠轴
中医药
connection between liver and large intestine
gut microbiota
atherosclerosis
gut-liver axis
traditional Chinese medicine
