摘要
目的 探讨磁共振弥散加权成像(diffusion weighted imaging,DWI)联合动态对比增强磁共振成像(dynamic contrast enhanced-magnetic resonance imaging,DCE-MRI)技术在良恶性前列腺病变鉴别诊断中的应用价值。方法 选取122例经病理证实的前列腺病变患者,均行DWI和DCE-MRI检查,分别比较DWI、DCE-MRI技术及两者联合诊断对良恶性前列腺病变的鉴别诊断效能,绘制受试者工作特征(receiver operating characteristic,ROC)曲线并计算曲线下面积(area under curve,AUC)。结果 122例前列腺病变中63例为前列腺癌、59例为良性前列腺病变。两者联合诊断的特异度、准确率、灵敏度、阳性预测值和阴性预测值分别为98.31%、96.83%、97.54%、98.39%、96.67%,高于DWI(86.44%、79.37%、82.79%、86.21%、79.69%)、DCE-MRI(83.05%、76.19%、79.51%、82.76%、76.56%)单独诊断,其中准确率、灵敏度和阴性预测值的比较差异有统计学意义(P<0.01);特异度和阳性预测值比较差异无统计学意义(P>0.01)。两者联合诊断鉴别前列腺病变良恶性的AUC为0.975(95%CI:0.927~0.999)高于DWI单独诊断的AUC为0.828(95%CI:0.787~0.869)和DCE-MRI单独诊断的AUC为0.795(95%CI:0.755~0.835)。结论 DWI联合DCE-MRI技术在良恶性前列腺病变鉴别诊断中的应用价值高于两者单独。
Objective To evaluate the application value of magnetic resonance diffusion-weighted imaging(DWI)combined with dynamic contrast-enhanced imaging(DCE-MRI)in the differential diagnosis of benign and malignant prostate lesions.Methods The clinical data of 122 patients with pathologically confirmed prostate lesions were selected.DWI and DCE-MRI imaging techniques were used to compare the diagnostic efficacy of DWI,DCE-MRI and their combination in the differential diagnosis of benign and malignant prostate lesions and the value of area under the receiver working curve(ROC)Results 122 cases of prostate lesions,including 63 cases of prostate cancer and 59 cases of benign prostate lesions.The specificity,coincidence rate,sensitivity,positive predictive value and negative predictive value of the combined diagnosis were 98.31%,96.83%,97.54%,98.39%and 96.67%,respectively,which were higher than 86.44%,79.37%,82.79%,86.21%,79.69%and 83.05%,76.19%,79.51%,82.76%,and 76.56%diagnosed by DWI and DCE-MRI alone.There were significant differences in coincidence rate,sensitivity and negative predictive value(P<0.01).There was no significant difference in specificity and positive predictive value(P>0.01).The area under curve AUC=0.975 of combined diagnosis of benign and malignant prostate lesions(95%CI:0.927-0.999)was higher than that of AUC=0.828(95%CI:0.787-0.869)diagnosed by DWI alone and AUC=0.795(95%CI:0.755-0.835)diagnosed by DCE-MRI alone.Conclusion The application value of DWI combined with DCE-MRI imaging in the differential diagnosis of benign and malignant prostate lesions is higher than that of both alone.
作者
殷超
赵卫忠
刘良卿
许建兴
张静
YIN Chao;ZHAO Weizhong;LIU Liangqing;XU Jianxin;ZHANG Jing(Department of Radiology,The Wujin clinical college of Xuzhou Medical University,The Affiliated Wujin Hospital of Jiangsu University,Changzhou 213002,China;Department of Radiology,Changzhou Third People's Hospital,Changzhou 213000,China)
出处
《医学影像学杂志》
2025年第7期96-100,共5页
Journal of Medical Imaging
基金
江苏省高校重点实验室开放研究课题(编号:XZSYSKF2023026)。
关键词
前列腺病变
磁共振成像
弥散加权成像
Prostate lesions
Magnetic resonance imaging
Diffusion weighted imaging
