摘要
近年来我国食管鳞状细胞癌的发病率和死亡率呈上升趋势,但由于食管位置的特殊性及临床症状不典型性的特点,导致疾病发现晚,治疗效果不尽人意。随着消化道微生态研究的不断进展,在探究食管鳞状细胞癌和微生态之间的关系时,发现具核梭杆菌和牙龈卟啉单胞菌在食管鳞状细胞癌患者的食管菌群中丰度较健康者增高。本文总结二菌与食管鳞状细胞癌的相关性,为今后探究食管鳞状细胞癌的发病机制提供新思路。
In recent years,the incidence and mortality of esophageal squamous cell carcinoma have been increased in China.Due to the special location of the esophagus and the characteristics of atypical clinical symptoms,it leads to late detection of the disease and unsatisfactory therapeutic effects.With the continuous progress of microecological research in the digestive tract,Fusobacterium nucleatum and Porphyromonas gingivalis have a certain influence on the changes of esophageal flora in patients with esophageal squamous cell carcinoma.The review summarizes the correlation between the two bacteria and esophageal squamous cell carcinoma which provides new ideas to explore the pathogenesis of esophageal squamous cell carcinoma.
作者
李鸿睿
胡海清
LI Hongrui;HU Haiqing(Inner Mongolia Medical University,Hohhot,China,010000;Endoscopy Center,Inner Mongolia Medical University Affiliated Cancer Hospital,Hohhot,China,010000)
出处
《食管疾病》
2025年第2期143-147,156,共6页
Journal of Esophageal Diseases
基金
国家自然科学基金项(82460118)
内蒙古自治区自然科学基金面上项目(2024MS08002)
内蒙古自治区医师协会临床医学研究与新临床技术推广项目(YSXH2024KYF068)
北京大学肿瘤医院内蒙古医院高水平临床专科建设项目(2024YNZD002)
内蒙古医学科学院公立医院联合基金项目(2024GLLH0390)
内蒙古医科大学重点项目(YKD2023ZD001)。
关键词
食管鳞状细胞癌
具核梭杆菌
牙龈卟啉单胞菌
esophageal squamous cell carcinoma
Fusobacterium nucleatum
Porphyromonas gingivalis
