摘要
人体口腔微生物种类复杂且数目庞大,其构成及分布可受到多种因素的影响。随着宏基因组学技术的发展,口腔菌群在肿瘤发生发展中的重要作用逐渐受到广泛关注。本文通过检索PubMed、Embase、中国知网、万方数据知识服务平台等数据库,对口腔菌群的影响因素及其与口腔癌、食管癌、胃癌关联的研究现况进行了总结,发现口腔菌群可受到性别、年龄、种族和生活习惯等多种因素影响,特定口腔菌群与上消化道肿瘤的发病风险相关,具有作为上消化道肿瘤初筛标志物的潜能。本文通过综述口腔菌群的影响因素及其与上消化道肿瘤关联性研究进展,旨在为探索上消化道肿瘤病因提供微生物组学的新方向,为优化、完善上消化道肿瘤高危人群的早期筛查及早诊早治方案提供科学依据。
The composition of human oral microorganism is numerous and complex and is easily affected by many factors.With the development of metagenomic technology,the important role of oral microbiome in the development of tumor has attracted extensive attention.A literature retrieval was conducted through PubMed,Embase,CNKI and WanFang database for an analysis on the characteristics of oral bacteria and its association with oral cancer,esophageal cancer and gastric cancer.The results indicated that oral microbiome can be influenced by age,gender,race,and lifestyle.Specific oral bacteria were associated with high risk of upper gastrointestinal cancer,indicating a potential role of oral microbiota to be the biomarker for upper gastrointestinal cancer.This paper summarizes the progress in the research of the association between oral microbiome and upper gastrointestinal cancer,showing a new direction for the exploration of microbiological etiology of upper gastrointestinal cancer and providing scientific evidence for the optimization of early detection and treatment of upper gastrointestinal cancer.
作者
邵丹彤
李敏娟
陈茹
魏文强
Shao Dantong;Li Minjuan;Chen Ru;Wei Wenqiang(National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2020年第7期1160-1164,共5页
Chinese Journal of Epidemiology
基金
国家重点研发计划(2016YFC0901400)
中国医学科学院医学与健康科技创新工程协同创新团队项目(2016-I2M-3-001)
北京协和医学院中央高校基本科研业务费专项资金(3332019139)
中国医学科学院中央级公益性科研业务费(2018PT32012)。
关键词
口腔菌群
上消化道肿瘤
影响因素
肿瘤标志物
Oral microbiome
Upper gastrointestinal cancer
Influence factor
Tumor biomarker
