摘要
目的探究中性粒细胞与淋巴细胞比值(NLR)联合血小板与淋巴细胞比值(PLR)对儿童全身炎性反应综合征(SIRS)早期预测价值。方法回顾性选择2021年1月至2023年2月合肥市第八人民医院诊治的136例SIRS患儿(SIRS组)和同期120例健康儿童(对照组)为研究对象。比较两组炎性反应指标和外周血NLR、PLR水平,采用Pearson检验分析SIRS患儿NLR、PLR与其他炎性反应指标的相关性,采用受试者工作特征(ROC)曲线分析NLR、PLR单独及联合检测对SIRS的预测价值。结果SIRS组血清降钙素原(PCT)、C-反应蛋白(CRP)和白细胞介素-6(IL-6)水平高于对照组[(1.56±0.41)μg/L比(0.57±0.15)μg/L、(56.04±17.71)mg/L比(4.50±1.38)mg/L、(8.54±1.95)ng/L比(0.95±0.21)ng/L],差异有统计学意义(P<0.05)。SIRS组外周血NLR、PLR水平高于对照组(4.08±1.32比2.01±0.58、269.15±80.09比194.01±62.41),差异有统计学意义(P<0.05)。Pearson检验结果显示,SIRS患儿外周血NLR、PLR水平与血清PCT、CRP和IL-6水平呈正相关(r=0.245、0.540、0.492、0.282、0.365、0.721,P<0.05)。ROC曲线分析结果表明,NLR、PLR联合检测预测SIRS的曲线下面积为0.747(95%CI 0.650~0.828),高于任一单项指标。结论外周血NLR、PLR水平与SIRS患儿发病相关,两者联合检测对儿童SIRS早期诊断具有一定的临床价值。
Objective To explore the predictive value of neutrophil-to-lymphocyte ratio(NLR)combined with platelet-to-lymphocyte ratio(PLR)in early stage of systemic inflammatory response syndrome(SIRS)in children.Methods A total of 136 children with SIRS(SIRS group)and 120 healthy children(control group)diagnosed and treated in the Eighth People′s Hospital of Hefei from January 2021 to February 2023 were retrospectively selected as the study objects.Inflammatory response indicators and peripheral blood NLR and PLR levels were compared between the two groups.Pearson test was used to analyze the correlation between NLR and PLR and other inflammatory response indicators in children with SIRS.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of NLR and PLR alone and combined detection for SIRS.Results The levels of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)in the SIRS group were higher than those in the control group:(1.56±0.41)μg/L vs.(0.57±0.15)μg/L,(56.04±17.71)mg/L vs.(4.50±1.38)mg/L,(8.54±1.95)ng/L vs.(0.95±0.21)ng/L,there were statistical differences(P<0.05).The levels of NLR and PLR of peripheral blood in the SIRS group were higher than those in the control group:4.08±1.32 vs.2.01±0.58,269.15±80.09 vs.194.01±62.41,there were statistical differences(P<0.05).The results of Pearson test showed that the levels of NLR and PLR of peripheral blood were positively correlated with the levels of serum PCT,CRP and IL-6(r=0.245,0.540,0.492,0.282,0.365,0.721,P<0.05).The ROC curve analysis results showed that the area under the curve of the combined NLR and PLR detection to predict SIRS was 0.747(95%CI 0.650-0.828),which was higher than the single index.Conclusions The levels of NLR and PLR of peripheral blood are related to the incidence of SIRS in children.The combined prediction of the two index can further improve the accuracy of early prediction.
作者
蒋炜
周家俊
袁增权
Jiang Wei;Zhou Jiajun;Yuan Zengquan(Department of General Pediatrics,the Eighth People′s Hospital of Hefei,Hefei 238000,China)
出处
《中国医师进修杂志》
2025年第6期539-542,共4页
Chinese Journal of Postgraduates of Medicine
