摘要
目的探讨正常体质量中老年人群血清铁蛋白(SF)及血脂水平与高尿酸血症的关联性。方法回顾性选取2019年1月至2021年12月在复旦大学附属中山医院吴淞医院进行健康体检的人群,从中筛选出符合正常体质量指数(BMI)标准的受检者,共计1671例。收集入选者体检资料,包括空腹血糖(FPG)、尿酸、肌酐(CREA)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及SF水平。将SF、TC、LDL-C、HDL-C按四分位数进行分组,采用线性回归和Pearson检验分析SF、TC、LDL-C、HDL-C与高尿酸血症之间的关联性。结果1671例体质量正常的中老年人中,高尿酸血症250例,高尿酸血症患病率为14.96%(250/1671)。Pearson检验结果表明,SF水平和尿酸水平呈中度正相关(r=0.500,P<0.01);TC水平和尿酸水平呈微弱正相关(r=0.250,P<0.01);HDL-C水平与尿酸水平呈中度负相关(r=-0.333,P<0.01);LDL-C水平与尿酸水平呈弱到中度正相关(r=0.380,P<0.01);另外,性别(男性)与尿酸水平呈中度正相关(r=0.575,P<0.01);CREA与尿酸水平呈正相关(r=0.620,P<0.05)。结论在体质量正常的中老年人群中,性别、TG、TC、LDL-C和SF与尿酸水平都呈正相关,其中性别、CREA和SF与尿酸水平的相关性较强,HDL-C与尿酸水平呈负相关。
Objective To investigate the association between serum ferritin(SF),blood lipid levels and hyperuricemia in middle-aged and elderly individuals with normal body mass(BMI).Methods A retrospective study was conducted on 1671 participants with normal BMI from health check-ups at Wusong Hospital of Zhongshan Hospital,Fudan University from January 2019 to December 2021.Collected data included fasting plasma glucose(FPG),uric acid,creatinine(CREA),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and SF levels.SF,TC,LDL-C,and HDL-C were grouped by quartiles,linear regression and Pearson correlation analysis used to assess their associations with hyperuricemia.Results Among 1671 normal-weight middle-aged and elderly individuals,250 cases of hyperuricemia were identified,yielding a prevalence of 14.96%(250/1671).Pearson analysis revealed:a moderate positive correlation between SF and uric acid levels(r=0.500,P<0.01);a weak positive correlation between TC and uric acid levels(r=0.250,P<0.01);a moderate negative correlation between HDL-C and uric acid levels(r=-0.333,P<0.01);a weak-to-moderate positive correlation between LDL-C and uric acid levels(r=0.380,P<0.01).Additionally,male gender showed a moderate positive correlation with uric acid levels(r=0.575,P<0.01),while CREA demonstrated a positive correlation with uric acid(r=0.620,P<0.05).Conclusions In normal-weight middle-aged and elderly populations,gender,TG,TC,LDL-C and SF exhibite positive correlations with uric acid levels,with stronger associations observed for gender,CREA,and SF.HDL-C show a negative correlation with uric acid levels.
作者
葛海蓉
郑炜斌
沈君
Ge Hairong;Zheng Weibin;Shen Jun(Department of General Medicine,Wusong Hospital of Zhongshan Hospital,Fudan University,Shanghai 200940,China;Department of Health Examination,Wusong Hospital of Zhongshan Hospital,Fudan University,Shanghai 200940,China)
出处
《中国医师进修杂志》
2025年第6期534-538,共5页
Chinese Journal of Postgraduates of Medicine
基金
上海市宝山区科学技术委员会科技创新专项资金项目(2023-E-08)。
关键词
血清铁蛋白
胆固醇
高尿酸血症
相关性
Serum ferritins
Cholesterol
Hyperuricemia
Correlationship
