摘要
目的探究多层螺旋CT灌注成像参数与血清协同刺激分子B7家族3(B7-H3)、甲胎蛋白异质体3(AFP-L3)的相关性及对肝细胞肝癌的诊断价值。方法回顾性选择2021年5月至2022年5月湖州市第一人民医院收治的50例肝细胞肝癌患者(研究组)和同期参加体检的40例健康体检者(对照组)为研究对象,比较两组多层螺旋CT灌注成像参数及血清B7-H3、AFP-L3水平,采用Pearson检验和受试者工作特征(ROC)曲线分析多层螺旋CT灌注参数与血清B7-H3、AFP-L3水平的相关性及其对肝细胞肝癌的诊断价值。结果研究组血流量(BF)、肝动脉灌注量(AP)、血容量(BV)、平均通过时间(MTT)及血清B7-H3、AFP-L3水平高于对照组[(213.72±35.01)ml/(100 g·min)比(126.17±14.01)ml/(100 g·min)、(152.37±30.45)ml/(100 g·min)比(18.21±1.21)ml/(100 g·min)、(25.89±3.01)ml/(100 g·min)比(23.62±2.37)ml/(100 g·min)、(19.32±3.58)s比(5.12±1.03)s、(401.35±42.37)ng/L比(221.38±23.01)ng/L、(353.47±40.35)mg/L比(291.12±23.45)mg/L],差异均有统计学意义(P<0.05)。Pearson检验结果表明,肝细胞肝癌患者BF、AP、BV、MTT与血清B7-H3、AFP-L3水平呈正相关(P<0.05)。ROC曲线分析结果显示,BF、AP、BV、MTT联合诊断肝细胞肝癌的曲线下面积高于单项指标(P<0.05)。结论肝细胞肝癌患者多层螺旋CT灌注参数BF、AP、BV、MTT水平及血清B7-H3、AFP-L3水平升高,且多层螺旋CT灌注参数与血清B7-H3、AFP-L3具有相关性,对肝细胞肝癌具有较高的诊断价值。
Objective To explore the correlation between perfusion parameters of multi-slice spiral CT and serum costimulating molecules B7 family 3(B7-H3),alpha-fetoprotein anisoplast 3(AFP-L3)and its diagnostic value in hepatocellular carcinoma.Methods Fifty patients with hepatocellular carcinoma admitted to the Huzhou First People′s Hospital from May 2021 to May 2022(study group)and 40 healthy subjects who participated in physical examination during the same period(control group)were retrospectively selected as the study objects.Perfusion imaging parameters of multi-slice spiral CT and serum B7-H3 and AFP-L3 levels were compared between the two groups.Pearson test and receiver operating characteristic(ROC)curve were used to analyze the correlation between perfusion parameters of multi-slice spiral CT and serum B7-H3 and AFP-L3 levels and its diagnostic value in hepatocellular carcinoma.Results The levels of blood flow(BF),hepatic artery perfusion(AP),blood volume(BV),mean transit time(MTT)and serum levels of B7-H3 and AFP-L3 in the study group were higher than those in the control group:(213.72±35.01)ml/(100 g·min)vs.(126.17±14.01)ml/(100 g·min),(152.37±30.45)ml/(100 g·min)vs.(18.21±1.21)ml/(100 g·min),(25.89±3.01)ml/(100 g·min)vs.(23.62±2.37)ml/(100 g·min),(19.32±3.58)s vs.(5.12±1.03)s,(401.35±42.37)ng/L vs.(221.38±23.01)ng/L,(353.47±40.35)mg/L vs.(291.12±23.45)mg/L,there were statistical differences(P<0.05).The results of Pearson test showed that BF,AP,BV,MTT were positively correlated with serum B7-H3 and AFP-L3 levels in hepatocellular carcinoma patients(P<0.05).ROC curve analysis results showed that the area under the curve of BF,AP,BV and MTT combined diagnosis of hepatocellular carcinoma was higher than that of single index(P<0.05).Conclusions Multi-slice spiral CT perfusion parameters BF,AP,BV,MTT and serum levels of B7-H3,AFP-L3 are increase and have positively correlated in the hepatocellular carcinoma patients,and multi-slice spiral CT perfusion parameters have high diagnostic value for hepatocellular carcinoma.
作者
刘阳
李鸣鹤
孙羽凡
Liu Yang;Li Minghe;Sun Yufan(Department of Radiology,Huzhou First People′s Hospital,Huzhou 313000,China)
出处
《中国医师进修杂志》
2025年第6期485-488,共4页
Chinese Journal of Postgraduates of Medicine
基金
浙江省基础公益研究计划项目(2019GY34)。
关键词
癌
肝细胞
灌注成像
协同刺激分子B7家族3
甲胎蛋白异质体3
Carcinoma,hepatocellular
Perfusion imaging
Costimulatory molecules B7 family 3
Alpha-fetoprotein anisoplast 3
