摘要
目的研究新生儿败血症继发急性肾损伤(AKI)诊断中联合检测血清胱抑素C(CysC)与视黄醇结合蛋白(RBP)的效果。方法根据是否继发AKI将我院2016年1月至2021年12月收治的52例败血症新生儿分为两组,A组26例继发AKI,B组26例均未继发AKI,另以同期在我院出生的26名健康新生儿为对照组,三组均取血样检测CysC、RBP水平,比较三组CysC、RBP水平差异及联合检测的效果。结果入院7d内A组CysC、RBP水平高于B组与对照组(P<0.05),B组与对照组比较无明显差异(P>0.05);CysC检测准确率、特异度及灵敏度分别为70.51%、65.38%、80.77%,RBP检测准确率、特异度及灵敏度分别为78.21%、82.69%、69.23%,联合检测准确率、特异度及灵敏度分别为91.03%、90.38%、92.31%,联合检测的准确率及特异度均高于单独检测(P<0.05),灵敏度比较无明显差异(P>0.05);AKIⅡ期、Ⅲ期新生儿CysC、RBP水平明显高于AKIⅠ期(P<0.05);有合并症、预后不良新生儿CysC、RBP水平高于无合并症、预后良好新生儿(P<0.05)。结论CysC、RBP联合检测对新生儿败血症继发AKI具有较高的诊断敏感度与特异度。
Objective To study the effect of combined detection of serum cystatin C(CysC)and retinol binding protein(RBP)in the diagnosis of acute renal injury(AKI)secondary to neonatal sepsis.Methods 52 newborns with sepsis treated in our hospital from January 2016 to December 2021 were divided into two groups according to whether they had secondary AKI.26 cases in group A had secondary AKI,and 26 cases in group B had no secondary AKI.In addition,26 healthy newborns born in our hospital at the same time were taken as the control group.Blood samples were taken from the three groups to detect the levels of CysC and RBP,and the difference of CysC and RBP levels among the three groups and the effect of combined detection were compared.Results Within 7 days after admission,the levels of CysC and RBP in group A were higher than those in group B and control group(P<0.05),and there was no significant difference between group B and control group(P>0.05);The accuracy,specificity and sensitivity of CysC were 70.51%,65.38%and 80.77%respectively,the accuracy,specificity and sensitivity of RBP were 78.21%,82.69%and 69.23%respectively,and the accuracy,specificity and sensitivity of combined detection were 91.03%,90.38%and 92.31%respectively.The accuracy and specificity of combined detection were higher than those of single detection(P<0.05),and there was no significant difference in sensitivity(P>0.05);The levels of CysC and RBP in neonates with AKI stageⅡandⅢwere significantly higher than those of AKI stageⅠ,(P<0.05);The levels of CysC and RBP in neonates with complications and poor prognosis were higher than those in neonates without complications and with good prognosis(P<0.05).Conclusion The combined detection of CysC and RBP has high sensitivity and specificity in the diagnosis of AKI secondary to neonatal sepsis.
作者
张轲
宋朝宾
ZHANG Ke;SONG Chao-bin(Department of Laboratory,Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007,Henan Province,China)
出处
《罕少疾病杂志》
2023年第1期95-96,107,共3页
Journal of Rare and Uncommon Diseases
