摘要
目的分析不同栓塞剂在肝癌经股动脉介入治疗中应用的临床效果。方法回顾性分析2020年1月至2022年12月解放军第九六〇医院收治的140例行肝癌经股动脉介入治疗患者的临床资料,其中栓塞剂应用碘化油的35例患者作为A组,应用无水乙醇的35例患者作为B组,应用明胶海绵颗粒栓塞剂的35例患者作为C组,应用载药微球栓塞剂的35例患者作为D组,比较四组患者临床疗效以及治疗前后的血清肿瘤标志物,并统计四组不良反应发生情况。结果四组总有效率比较差异有统计学意义(P<0.05),其中D组总有效率最高[97.14%(34/35)],其次为C组[85.71%(30/35)],A组和B组[54.29%(19/35)、62.86%(22/35)]总有效率较低。四组治疗后甲胎蛋白(AFP)、癌胚抗原(CEA)、碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)及甲胎蛋白异质体L3(AFP-L3)水平较治疗前均降低(P<0.05),且四组间上述指标比较差异有统计学意义(P<0.05),其中,D组AFP、CEA、ALP、GGT和AFP-L3水平最低,其次为C组,A组和B组偏高。四组不良反应总发生率比较差异无统计学意义(P>0.05)。结论碘化油、无水乙醇、明胶海绵颗粒栓塞剂和载药微球栓塞剂在肝癌经股动脉介入治疗中应用的安全性无明显差异,在疗效方面比较发现,载药微球栓塞剂疗效最好,其次为明胶海绵颗粒栓塞剂,碘化油栓塞剂和无水乙醇疗效较差。
Objective To analyze the influence of embolic agent type selection on the clinical efficacy of transfemoral artery interventional therapy for hepatocellular carcinoma.Methods The clinical data of 140 cases of hepatocellular carcinoma patients treated with femoral artery interventional therapy in the 960th Hospital of the Joint Logistic Support Force of the PLA from January 2020 to December 2022 were retrospectively analyzed.Among them,35 patients treated with iodized oil was in group A,35 patients treated with anhydrous ethanol was in group B,35 patients treated with gelatin sponge granule embolization agent was in group C,35 patients treated with drug-loaded microsphere embolization agents was in group D.The clinical efficacy and serum tumor markers before and after treatment of the four groups were compared,and the occurrence of adverse reactions in the four groups were analyzed.Results There was statistical significance in the total effective rate of the four groups(P<0.05),among which the total effective rate of group D was the highest[97.14%(34/35)],followed by group C[85.71%(30/35)],and the total effective rate of group A and B[54.29%(19/35),62.86%(22/35)]was lower.After treatment,the levels of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),alkaline phosphatase(ALP),γ-glutamyltransferase(GGT)and alpha-fetoprotein anisoplast L3(AFP-L3)were all decreased compared with those before treatment(P<0.05),and there were statistically significant differences in the above indexes among the four groups(P<0.05).Among them,the levels of AFP,CEA,ALP,GGT and AFP-L3 in group D were the lowest,followed by group C,and higher in group A and B.There was no significant difference in the total incidence of adverse reactions among the four groups(P>0.05).Conclusions There is no significant difference in the safety of oil iodide,anhydrous ethanol,gelatin sponge particles embolic agent and drug-carrying microspheres embolic agent applied in transfemoral interventional therapy of hepatocellular carcinoma,and in the comparison of the efficacy,it is found that the drug-carrying microspheres embolic agent have the best efficacy,followed by gelatin sponge particles embolic agent,and oil iodide embolic agent and anhydrous ethanol are poor.
作者
任振飞
刘晓
郭春霞
毕林林
王斐
Ren Zhenfei;Liu Xiao;Guo Chunxia;Bi Linlin;Wang Fei(Department of Oncology,the 960th Hospital of the Joint Logistic Support Force of the PLA,Jinan 250000,China)
出处
《中国医师进修杂志》
2025年第6期515-519,共5页
Chinese Journal of Postgraduates of Medicine
关键词
肝肿瘤
股动脉
栓塞
治疗性
栓塞剂
Liver neoplasms
Femoral artery
Embolization,therapeutic
Embolic agent
