摘要
随着全球糖尿病患者持续增加,糖尿病认知障碍发病率日益上升,因此,探索糖尿病认知障碍病理机制与干预策略具有重要意义。当归芍药散作为经典方剂,有补血化瘀,健脾调肝之效,其主要成分为多糖类、生物碱类、挥发油等。当归芍药散可通过调节AMP依赖蛋白激酶(AMPK)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、有丝分裂原-活化蛋白激酶/细胞外信号调节蛋白激酶(MAPK/ERK)等多条通路,协同改善脑部损伤,减缓糖尿病认知障碍进程。本文通过查阅文献,总结当归芍药散治疗糖尿病认知障碍作用机制及药效基础,旨为当归芍药散的临床应用提供参考。
With the continuous increase in the global number of diabetic patients,the incidence of diabetes-associated cognitive dysfunction has been rising,making it significant to explore the pathological mechanisms and intervention strategies for diabetic cognitive impairment.Danggui Shaoyao San,as a classic formula,is known for its effects in tonifying blood,activating blood circulation,strengthening the spleen,and regulating the liver.Its main components include polysaccharides,alkaloids,volatile oils,and others.Danggui Shaoyao San exerts its effects by regulating multiple pathways,such as AMP-activated protein kinase(AMPK),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK),and others.These pathways work synergistically to improve brain injury and slow the progression of diabetes-associated cognitive dysfunction.This article reviews the mechanisms and pharmacological basis of Danggui Shaoyao San in the treatment of diabetes-associated cognitive impairment,aiming to provide references for its clinical application.
作者
焦涵婷
申芳茹
吉祥
张雪芹
付新
JIAO Hanting;SHEN Fangru;JI Xiang;ZHANG Xueqin;FU Xin(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Lishui University,Lishui 323000,China)
出处
《中医药学报》
2025年第5期114-120,共7页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金面上项目(81973746)
黑龙江省青年科学基金项目(QC2017114)。
关键词
当归芍药散
物质基础
糖尿病认知障碍
Danggui Shaoyao San
Material basis
Diabetes-associated cognitive dysfunction
