摘要
血管内皮损伤标志物是评估血管内皮功能的重要指标,可为心血管疾病(CVD)的诊断和治疗提供依据。目前,经典的血管内皮损伤标志物,如C反应蛋白、细胞间黏附分子等,在CVD中的作用机制和临床意义已得到广泛研究,但其敏感性和特异性有限,难以全面反映CVD的发生发展过程。随着液体活检技术和新的分子生物学检测技术的发展,新型血管内皮损伤标志物成为研究热点。本文系统综述了血管内皮损伤标志物,并重点探讨新型标志物在CVD中的研究进展与应用价值。
Aim Biomarkers of vascular endothelial injury serve as crucial indicators for assessing vascular endothelial function and provide a basis for the diagnosis and treatment of cardiovascular diseases(CVD).Currently,the mechanisms and clinical significance of classical biomarkers,such as C-reactive protein and intercellular adhesion molecule,in CVD have been extensively studied.However,their limited sensitivity and specificity make it difficult to comprehensively reflect the progression of CVD.With the advancement of liquid biopsy and novel molecular biology detection technologies,emerging biomarkers of vascular endothelial injury have become a research focus.This article systematically reviews biomarkers of vascular endothelial injury,with a particular emphasis on the research progress and clinical applications of novel biomarkers in CVD.
作者
徐翼飞
吴弘
XU Yifei;WU Hong(Department of Cardiology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)
出处
《中国动脉硬化杂志》
2025年第5期455-460,共6页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(82070419)。
关键词
生物标志物
内皮细胞
心血管疾病
内皮细胞特异性分子1
biomarkers
endothelial cell
cardiovascular diseases
endothelial cell specific molecule-1
