摘要
目的探讨不稳定型心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)后血清内皮细胞特异性分子1(ESM-1)、低氧诱导因子1α(HIF-1α)水平与支架内再狭窄(ISR)的相关性。方法选取2018年3月—2019年4月于本院行PCI术的202例UAP患者为研究对象,根据术后随访1年内是否发生ISR将患者分为两组:ISR组56例和非ISR组146例。采用酶联免疫吸附法检测患者PCI术后24 h血清ESM-1、HIF-1α水平。分析血清ESM-1与HIF-1α水平对ISR的预测价值及影响ISR的因素。结果ISR组吸烟史比例、血糖、LDLC水平、血清ESM-1、HIF-1α水平高于非ISR组,差异有统计学意义(P<0.05)。UAP PCI术后ISR患者血清ESM-1水平与HIF-1α水平呈正相关(r=0.545,P<0.05)。血清ESM-1、HIF-1α预测UAP患者PCI术后ISR的ROC曲线下面积(AUC)分别为0.913、0.851,特异度分别为87.0%、74.0%,灵敏度分别为82.1%、85.7%;二者联合预测的AUC为0.936,特异度为91.8%,灵敏度为78.6%。ESM-1(≥2.42μg/L)、吸烟是影响UAP患者PCI术后ISR的独立危险因素(P<0.05)。结论UAP患者PCI术后血清ESM-1、HIF-1α水平增高与ISR发生密切相关。
Aim To investigate the correlation between serum endothelial cell specific molecule-1(ESM-1),hypoxia-inducible factor-1α(HIF-1α)levels and in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)in patients with unstable angina pectoris(UAP).Methods 202 patients with UAP who underwent PCI in our hospital from March 2018 to April 2019 were selected as the research objects.According to whether ISR occurred within 1 year of postoperative follow-up,the patients were divided into two groups:56 cases in ISR group and 146 cases in non-ISR group.Enzyme-linked immunosorbent assay was used to detect serum ESM-1 and HIF-1αlevels in patients 24 h after PCI.The predictive value of serum ESM-1 and HIF-1αlevels on ISR and the factors affecting ISR were analyzed.Results The proportion of smoking history,blood glucose,LDLC level,serum ESM-1 and HIF-1αlevels in the ISR group were higher than those in the non-ISR group,and the difference was statistically significant(P<0.05).Serum ESM-1 levels were positively correlated with HIF-1αlevels in ISR patients after UAP PCI(r=0.545,P<0.05).The area under the ROC curve(AUC)of serum ESM-1 and HIF-1αpredicting ISR in UAP patients after PCI were 0.913 and 0.851,respectively,the specificities were 87.0%and 74.0%,and the sensitivities were 82.1%and 85.7%,respectively;the AUC of the joint prediction of the two was 0.936,the specificity was 91.8%,and the sensitivity was 78.6%.ESM-1(≥2.42μg/L)and smoking were the independent risk factors affecting ISR in UAP patients after PCI(P<0.05).Conclusion Increased serum ESM-1 and HIF-1αlevels are closely related to the occurrence of ISR after PCI in UAP patients.
作者
周秀
朱洪斌
廖晓现
ZHOU Xiu;ZHU Hongbin;LIAO Xiaoxian(Department of Cardiology,Kaizhou District People s Hospital,Chongqing 405400,China)
出处
《中国动脉硬化杂志》
CAS
2022年第4期347-351,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81500224)。
