摘要
目的:基于基因-环境-内表型-行为模型,考察亲子关系、主观幸福感、5-HTR1A基因rs6295多态性对青少年亲社会行为的影响。方法:采取问卷法对701名初中学生进行调查,并结合DNA分型技术获取5-HTR1A基因的SNP位点。结果:(1)亲子关系显著正向预测青少年亲社会行为;(2)主观幸福感在亲子关系和亲社会行为之间起中介作用;(3)rs6295多态性在亲子关系与主观幸福感之间起调节作用,具体表现为,相比携带rs6295位点G/C和C/C基因型的个体,携带rs6295位点G/G基因型的个体亲子关系对主观幸福感的正向预测作用更强。结论:亲子关系显著正向预测青少年亲社会行为,主观幸福感在其中发挥中介作用,且rs6295多态性调节亲子关系对主观幸福感的影响。G/G基因型个体的亲子关系对主观幸福感的正向预测效应更强,G/G基因型为敏感基因型。
Objective:Based on the gene-environment-phenotype-behavior model,this study examined the influence of parent-child relationships,subjective well-being,and the 5-HTR1A gene rs6295 polymorphism on adolescent prosocial behavior.Methods:A questionnaire survey was conducted on 701 junior high school students,and DNA genotyping tech-niques were used to obtain SNP data for the 5-HTR1A gene.Results:(1)Parent-child relationships significantly predicted adolescent prosocial behavior;(2)Subjective well-being mediated the relationship between parent-child relationships and prosocial behavior;(3)rs6295 polymorphism played a regulating role in the relationship between parent-child relationship and subjective well-being.Specifically,compared with the individuals carrying the G/C and C/C genotypes of rs6295 locus,the parent-child relationship of individuals carrying the G/G genotype of rs6295 locus had a stronger predictive effect on subjective well-being.Conclusion:Parent-child relationship positively predicts adolescent prosocial behavior,in which subjective well-being plays an intermediary role,and rs6295 polymorphism moderates the influence of parent-child rela-tionship on subjective well-being.The positive predictive effect of parent-child relationship on subjective well-being of G/G genotypes is stronger,that is,G/G genotypes are sensitive genotypes.
作者
何震
詹林
曾子豪
刘双金
杨琴
胡义秋
HE Zhen;ZHAN Lin;ZENG Zihao;LIU Shuangjin;YANG Qin;HU Yiqiu(School of Educational Science,Hunan Normal University,Changsha 410081,China;Hunan Normal University Library,Changsha 410081,China;Research Center for Mental Health Education of Hunan Province,Changsha 410081,China;Cognition and Human Behavior Key Laboratory of Hunan Province,Changsha 410082,China)
出处
《中国临床心理学杂志》
北大核心
2025年第1期195-201,共7页
Chinese Journal of Clinical Psychology
基金
湖南省教育科学规划项目“青少年自杀意念到自杀行为:风险因子、机制与对策”(编号:XJK23AJD023)。
