摘要
目的 :探讨冠心病 (CHD)不同程度冠脉病变时胰岛素敏感性指数、血清脂质的变化及意义。方法 :2 9例CHD同时合并糖尿病的病人 ,按冠脉主要分支最大狭窄程度和斑块病变类型不同分为明显病变组 (SG)和轻度病变组 (MG) ,另取同期冠造正常非CHD者 16例为对照组 (CG)。测定各组空腹血糖、胰岛素和餐后 2小时血糖、胰岛素 ,胰岛素敏感指数 ,血清脂质水平。结果 :CHD同时合并糖尿病的病人各指标显著高于健康对照组 (P <0 .0 5 -0 .0 1) ,且冠脉明显病变组显著高于冠脉轻度病变组 (P <0 .0 5 )。结论 :上述各参数可能对于区分CHD冠脉病变程度具有预示价值 。
Objective: To investigate changes of insulin sensitivity index, serum lipid in coronary heart disease (CHD) with various degrees of coronary lesion and their significance.Method: On the basis of the degrees of coronary maximal stenoses and angiographic morphology of plaques, 29 patients with CHD were divided into two groups: 1) Severe lesion (SG, narrowing in luminal diameter ≥50% and type 2,3 of plaque morphology; 2) Mild lesion (MG, narrowing in luminal diameter <50% and type 1 of plaque morphology. Meanwhile, 16 healthy people (CG) were normal in coronary angiography. The fasting plasma glucose, postprandial 2h plasma glucose, fasting insulin, postprandial 2h insulin, insulin sensitivity index and serum lipid were determined.Results: The serum levels of fasting plasma glucose, postprandial 2h plasma glucose, fasting insulin, postprandial 2h insulin, insulin sensitivity index and serum llipid in CHD patients with diabetes were higher significantly than those in healthy controls (P<0.05-0.01). Meanwhile, These parameters above in the severe lesion group were much higher than those in the mild lesion group. Conclusion: These parameters above may be of predictable value in differing CHD patients with significant coronary lesion from those with mild coronary lesio. There are ocviously the effects of insulin resistance on coronary lesion in coronary heart disease with diabetes.
出处
《海南医学》
CAS
2002年第11期70-71,共2页
Hainan Medical Journal
关键词
冠心病
胰岛素抵抗
血脂
CHD
coronary heart disease Insulin resistance Serum lipid
