摘要
目的：分析一组不稳定性心绞痛（ＵＡ）患者冠状动脉造影ＩＩ型斑块的发生率、主动脉根部及冠状静脉窦（ＣＳ）血浆凝血烷Ｂ２（血栓素Ｂ２，ＴＸＢ２）及６－酮－前列腺素Ｆ１ａ。（６－酮－ＰＧＦ１ａ）含量的变化。方法：４２例患者（冠心病２９例，非冠心病１３例）纳为受试对象。对冠心病患者［稳定性心绞痛（ＳＡ）９例，ＵＡ２０例］进行了冠状动脉造影病变的形态学分析。对所有受试对象，同时采集升主动脉根部（ＡＯ）及ＣＳ血进行血浆ＴＸＢ２及６－酮－ＰＧＦ１ａ的测定（放射免疫分析法）。结果：ＵＡ患者ＩＩ型斑块的发生率明显高于ＳＡ者（６０％对１１．１％，Ｐ＜０．０５）；ＩＩ型斑块患者血浆ＴＸＢ２ＣＳ／ＡＯ比值明显大于其它斑块者及非冠心病患者（Ｐ＜０．０１，即使在ＵＡ患者中结果亦相似）。结论：ＵＡ患者ＩＩ型斑块的发生率高；ＵＡ患者的发病与斑块局部血小板激活和（或）血栓形成有关。
Objective:To examine the incidence of type II lesion at coronary angiography in patients with unstable angina,and the changes of plasma TXB2 and 6-keto-PGF1a from the aortic root (AO)and coronary sinus(CS).Methods: Forty-two cases, including 29 with coronary heart disease(CHD)and 13 without CHD as control,were studied. Angiographic morphology of the coronary lesions was assessed in patients with CHD.Blood samples for measurement of plasma TXB2 and 6-keto-PGF1a. by RIA were simultaneously taken from A0 and CS in all cases.Results:Type II lesions were more frequently found in the 20 patients with unstable angina(UA)than in the 9 patients with stable angina(60%vs.11.1%,p<0.05);patients with type II lesions had sig nificantly higher plasma TXB2 CS/AO ratios than those with other type lesions and in control group (2.06 ±0.25 vs.0.98±0.07 and 1.02±0.07,respectively,p<0.01), patients with UA had similar results Conclusion:Type II lesions are frequently found in patients with UA;and local platelet activation and thrombosis in the coronary circulation may play an important role in the pathogenesis of UA.
出处
《中国循环杂志》
CSCD
1996年第1期3-5,共3页
Chinese Circulation Journal
基金
国家自然科学基金
关键词
不稳定性心绞痛
心绞痛
冠状动脉造影
凝血e烷
Unstable angina
Coronary angiography
Thromboxane B2
Coronary circulation
