摘要
肺癌为全球发病率较高的恶性肿瘤之一,正虚邪实是其基本病机,因此治疗肺癌以益气活血为关键。黄芪-莪术药对是中医益气活血法常用药对,二者配伍具有益气化瘀功效,多项研究表明黄芪-莪术药对可用于治疗肺癌。通过以黄芪-莪术药对为核心,多角度综述其活性成分及抗肺癌作用机制,具体包括抑制细胞增殖、诱导细胞凋亡、抑制侵袭与迁移、抗肿瘤血管生成、调控肿瘤微环境、调节免疫功能等,为临床治疗肺癌提供参考。
Lung cancer is one of the malignant tumors with high incidence worldwide.Deficiency of vital energy and presence of pathogenic factors are its fundamental pathogenesis,hence the treatment of lung cancer is crucially focused on invigorating qi and activating blood circulation.Huangqi(Astragali Radix)-Ezhu(Curcumae Rhizoma)medicine pair is commonly used to nourish qi and promote blood circulation in traditional Chinese medicine.Combining the two has the effect of nourishing qi and removing blood stasis.Numerous studies have indicated that Astragali Radix-Curcumae Rhizoma pair can be used to treat lung cancer.By focusing on Astragali Radix-Curcumae Rhizoma pair,we reviewed its active components and mechanisms of action against lung cancer from multiple perspectives,including inhibiting cell proliferation,inducing apoptosis,inhibiting invasion and migration,anti-tumor angiogenesis,regulating the tumor microenvironment,and modulating immune functions,to provide references for the clinical treatment of lung cancer.
作者
周银杰
万籽晗
余沛霜
李遇伯
田淑峰
沈海波
ZHOU Yinjie;WAN Zihan;YU Peishuang;LI Yubo;TIAN Shufeng;SHEN Haibo(Ningbo No.2 Hospital,Ningbo 315016,China;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第21期7547-7556,共10页
Chinese Traditional and Herbal Drugs
基金
国家中医药管理局青年歧黄学者支持项目
天津市科技局重大专项与工程计划项目(21ZXJBSY00040)。
关键词
益气活血
黄芪
莪术
肺癌
黄芪多糖
黄芪甲苷
姜黄素
莪术醇
毛蕊异黄酮
tonifying qi and activating blood
Astragali Radix
Curcumae Rhizoma
lung cancer
Astragalus polysaccharides
astragaloside
curcumin
curcumol
calycosin
