摘要
功能性消化不良(functional dyspepsia, FD)是以胃和十二指肠区域功能障碍为主的非器质性疾病,中医学将其归为“痞满”和“胃脘痛”等范畴,并分为脾虚气滞、肝郁(肝胃不和、肝郁脾虚、肝郁气滞)、脾胃湿热、脾胃虚寒(弱)与寒热错杂等证型。中医药治疗FD效果明显且接受度高,而病证结合的动物模型是开展相关研究的基础和前提。因此,本文对现有的FD病证结合动物模型的研究进行整理和归纳,对具体造模方式和评价指标的选择原因进行探讨,同时提出目前研究的不足之处,以期为今后FD病证结合动物模型的研究提供支持。
Functional dyspepsia(FD)is a non-organic disease that is mainly due to regional dysfunction of the stomach and duodenum.In traditional Chinese medicine(TCM),it is classified as epigastric fullness and epigastric pain,and divided into the syndrome types of spleen deficiency and qi stagnation,spleen-stomach deficiency-cold(weak),spleen-stomach damp-heat,liver-stomach disharmony,and cold-heat complicated.TCM has a significant effect and high acceptance for treatment of FD,and the animal model with the combination of disease and syndrome is the basis and prerequisite for relevant research.Therefore,we organized and summarized the existing research on animal models of FD combined with disease and syndrome and explored the reasons for selection of specific modeling method and evaluation indicators.We identified the shortcomings of the current research to provide support for future research on animal models of FD combined with disease and syndrome.
作者
刘昊
王馨嫒
李文静
吴亚轩
王晨琪
肖洪玲
LIU Hao;WANG Xinai;LI Wenjing;WU Yaxuan;WANG Chenqi;XIAO Hongling(Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 301600,China;School of Nursing,Tianjin University of Traditional Chinese Medicine,Tianjin 301600)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第10期1342-1350,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(81403312)。
关键词
功能性消化不良
动物模型
病证结合
中医证候
functional dyspepsia
animal model
combination of disease and syndrome
TCM syndrome Conflicts of Interest:The authors declare no conflict of interest.
